NurdRage - 2017-09-09
In this video we finally make Pyrimethamine. Pyrimethamine is also known as Daraprim. Related videos: Make 2-(p-chlorophenyl)-3-oxopentanenitrile: https://www.youtube.com/watch?v=5oAZyhPx_ws Getting Guanidine Carbonate and Hydrochloride from No-Lye Hair Relaxants: https://www.youtube.com/watch?v=wmWTF3lBDEI Dean stark apparatus: https://www.youtube.com/watch?v=jxgpLp279Yc Make sodium metal: https://www.youtube.com/watch?v=jCrFFVVcPUI Extract ether from starter fluid: https://www.youtube.com/watch?v=r8MwwpSWeq4 Make Trimethyl Orthoformate: https://www.youtube.com/watch?v=TmUNTkP2nw0 Donate to NurdRage! Through Patreon (preferred): https://www.patreon.com/NurdRage Through Bitcoin: 1NurdRAge7PNR4ULrbrpcYvc9RC4LDp9pS Glassware generously provided by http://www.alchemylabsupply.com/ Use the discount code "nurdrage" for a 5% discount. Social media links: Twitter: https://twitter.com/NurdRage Facebook: https://www.facebook.com/NurdRageYoutube/ Instagram: https://www.instagram.com/nurdrageyoutube/
Martin Shkreli : it's not possible to make it cost effective.
NurdRage : hold my beer ...
2years later
NurdRage : take that "pharma bro" ! Where's my beer ?
This drug is avaible around the globe from diffrent sources. GSK sells it 0.66$/pill in the UK and exports it for 2.20$/pill in Canada. Imprimis Pharmaceuticals sell a combination of pyrimethamine and leucovorin in capsules for around 1$/pill in the USA. Yes, he did something terrible.
MonMalthias
It says RIGHT THERE on the page under "Other Products in Development" that they're developing "TRP-004 for toxoplasmosis".
i think you got brain problems my dude.
not really sorry bb
Martin Shkreli was right.
Let's hope YouTube doesn't flag this one. And remember: If you've turned on notificaitions or subscriptions and don't see my video in there (at least after an hour or so), report the bug to youtube to fix it. They'll listen to you more than they'll listen to me.
Anyway, thanks for standing by me. This would never have gotten done without all of you supporting me.
Break out the champagne, we've succeeded.
It was in my sub box!
NurdRage chalenge - extrast some metal from his ore without electrolicis and with domestic chemichals
what about this for a new project???
goo.gl/uWUN88
those are certainly some nice crystals
Charles Kogan That is a domestically available chemical already.
I have no idea what Pyrimethamine is or does, but, it's been a fascinating journey seeing all the different processes and reactions... :)
It treats the crazy cat lady disease?
No, you don't hear about it because Daraprim is 2 to 4 CENTS a pill in Brazil, while that Shkreil asshatt raised the price in the US from $13.50 a pill (already a ludicrous price) to $750.00 a pill
In the US this costs 750 dollar. per tablet. in Belgium this costs 30 tablets for 4.46 euro. 15 cent P/tablet..WTF
BEANTWOORDEN
@Jacob If you don't pay and the insurance company does, where do the insurance companies get the money????
@Don't Even Bother 5000% my guy not 1000
7:16 Gorgeous.
Congratulations, NurdRage. It's been a long and bumpy road, but you made it.
+1
tehlaser "where will he go? What will he do"
7:16 separates the undergrads from the PhDs
Congrats +NurdRage. The work finally paid off. Are you planning to publish this in a journal? We all hope you continue to do innovative projects in the future like this one.
A journal would be really nice :) I would really like to show this to my professor
Thumbing this message all the way. The discoveries you've made along the way, as well as the final process, need to be made more widely available than this youtube channel, please publish, and congratulations. It's been a fascinating few years and we look forward to watching whatever you do next!
I guess he did, but he will not say it because of conspiracy.
Pikefish Yeah, having this material on YouTube for amateurs and laymen is great, but this guy could do some real groundbreaking work!
Next challenge >> make Nile Red from domestically available chemicals 😂
Aleksander Sobolewski make another scientist buddy,hell yeh
+Alvis Nile red is a pigment, that NileRed really like, hence is channel name
A lab spill with mercury happened during the process,
We got Cody's Lab now
Congrats, i can't find the words to describe this. You're right, this is like building a computer from sand. But the result is awesome.
YouCubed22 ok but all the process aren't done by the same industry.
Yeah but that's still half the price this drug was at one point jumped up to, so congrats on that, 2 years later you did prove yourself very much right.
Joshua Nicoll That other half the price which then goes into paying for the research that goes into pioneering life saving drugs and more importantly paying for the absurdly long process of getting it passed by he FDA. Nurdrage took the L on this one.
"I don't think reactions performed in a soup can would pass any form of medical certification" Come on! That's how you know it's the good stuff! Thanks for all the inspiration!! #NurdRageisKing
I believe that's called "free range" 😉
In description
"This video is generously sponsored by:
…
Gary Johnson"
WAIT WHAT?!
The acetone contamination more than likely is from the nmr tube. Acetone is commonly used to clean the tubes and to get rid of all traces usually requires vacuum and IR lamp.
Aren't lots of nmr spectrums contaminated with acetone because it gets used to wash equipment regularly?
Actually this is a pretty common occurrence when people wash NMR tubes with acetone. Since they are so narrow if you are not careful and thorough in drying you see a residual acetone peak.
Pff. Just wash them with deuterated acetone...
I prefer washing with deuterated THF, but to each their own.
@ClickThisToSubscribe that is not very clever because there is no pure deuterated acetone so it will always generate a peak. its just a waste of money.
@Vornamed Nachnamed It was intented as a sarcastic comment, since deuterated acetone is very expensive to just wash things with. Sigma (sorry, Merck) sells it for about $4k per liter for 99.9 atom% deuterium...
Like +Charles Augustus said I think you should publish this in a science journal. You have proven that synthesis method and that it can be acomplished in an relatively amateur lab. Moreso you actually have video evidence on how to synthesize it from the beggining to end. As always nice work, you have my congratulations as always on the brilliant videos and brilliant chemistry +NurdRage. Keep up this awesome work, I wish my Chem teachers in college we're as engaging as you.
Whenever y get tired of studing and working hard , you make me remember why i'm studying chemistry , thanks
The people who thumb down this video are not very intelligent. This whole process of synthesizing this drug has been such a great learning opportunity and has expanded my point of view of OTC viability. Bravo Dr. Butyl Lithium AKA (NerdRage)! Your an amazing chemist.
Thank you for your persistence. The real achievements in life aren't always immediate. Bringing a task to completion (goal achieved or not) generally will reveal benefits that exceed expectation. ...........It's all about the journey.
_W
After two years of watching these amazing videos, seeing the layer of pyrimethamine appear between the ether and aqueous layer was amazingly satisfying. Well done, and thanks for all the hard work.
Congratulations !years of work finally paid off !
I call this ~dedication~. And no one, absolutely no one can contradict me.
Hats off to NurdRage!
Must... Resist... Watching 360p...
Just a little bit longer...
Congratulations! As chief of my department at Uni says, you've survived this project.
That's why I love chemestry, You can make anything from anything else.
Your channel is amazing, congratulations.
Got a notification and it showed up in my feed. Love your videos!
10:34 : still cheaper that the $750/tablet Turing Pharmaceutical charged...
Wow...just wow! I've been watching this channel for more than 5 years now and this is probably his best result. You're an inspiration for fellow researchers, like me. Thank you, Nurdrage!
Congratz, Dr N-Butyl Lithium, you made it finally xD
Nice. I love your channel
Congratulations! It's been fun to watch your progress along the way.
You said that you discovered a new way to produce sodium metal without using electrolysis. Will you publish this finding in a journal (or have you already done so)?
can you please make the whole procedure as one video, it will be interesting to see, even if over 1 hour
rt tr Yeah, a big start-to-finish compilation video would be great for people like me who weren’t along for the whole ride (I only discovered NurdRage, along with other YouTube chemists like NileRed and Cody’s Lab, a few months ago).
Amazing, Congratulations!!!!!
Congratulations I have been watching the whole way and I am very proud that you completed it. Thank you I have.learned a lot about home chemistry from you and love your content.
This has been a very informative and entertaining series. Congratulations on your well deserved success.
Wow, good job man! I remember a few years ago when you started trying to make this and you're finally here!
Genuinely impressive, you've made me appreciate and enjoy learning (Attempt to understand ) chemistry in a way my teachers never did :)
Yes! Finally! You're awesome!
I'm extremely impressed, give yourself a pat on the back.
I'm so happy for you nurd, i've been watching this since day one and i've loved it every step of the way. Congrats Nurd!!!
It's been over a year. I reviewed all the steps and am still amazed. Again, Congrats.
Congrats on finally finishing this pathway, it feels like it's been ages since you began!
Well done! I haven't been here for the whole process as a lot of organic reactions are a bit too complex for an amateur-amateur like me.
But anyone can see it's worth celebrating when you come out of two years research with a big green tick in the checkbox.
Keep up the great work... you are the one person who made me realise that YouTube wan't just about pirated music videos and people hiding turds in each others lunchboxes.
He sounds like the "do you find something comical about my appearance while I am driving my automobile?" guy
12:28 awesome quote!.. Congratulations on the successful endeavor & sharing your knowledge along the way. :)
Thanks for 2 years of "he is really going to do it!!" fun. Hopefully you do something in future also.
I have enjoyed watching you go through this entire process from day one! Congratulations! Thank you for being persistant through even the failures along the way.
I have a challenge for you, separate hydrogen peroxide from sodium percarbonate (OxiClean). H2O2 is hard to get and make for the hobbyist.
You can get it for pennies. Its not hard to get.
where? Its like 13 usd for about 400ml of concentrated peroxide. I want gallons of the stuff
why?
I want to make a peroxide rocket. atleast sometime before I die. not really in a hurry.
Look up Guardian of Eden. They sell gallon jugs of 35% for $40. I've been buying from them for the last decade, good stuff for a good price.
Awesome man! I can only imagine how hard it was to get to this point, so you should be proud! Congratz from a fellow chemist :)
AWESOME! You did it. I've been following this adventure for the whole time :)
This is my third time watching this video. I only have one thing to say. Thank you :).
so at the end of the day, is it easier to take an advance chemist course or just to buy the stuff?
This is amazing! I loved your work and the final product looks really clean.
SmarterEveryDay - 2017-09-10
I love the deep introspection after such a huge accomplishment. Congratulations!
NurdRage - 2017-09-10
Thanks! I appreciate it!
Stoneman66666 - 2017-09-16
Oh man, Destin has been following along? Nice to see you man, I'd love to see a collaboration between you two!