Chemiolis - 2023-02-01
Doing this project has been a goal of mine for many years and it finally happened (proud chemistry noises)! NO MORE SAMPLES ARE AVAILABLE!!!!!!!
there's nothing quite like finding a new chemistry channel to binge
rightt
When Nile red is taking too long
This is my first video of his too, I'm 45 seconds in or so lmao.
Already know I'm gonna be watching more.
@@shebahammy haha yes 😂😂
I just found this channel and I concur!
17:03 you know you’re not feeling great about your yield when you suddenly feel the need to add a decimal
"after 100 years, it has all filtered through"
We're all familiar with that! I do enjoy that anhydrous humour.
Interesting last name Eddie
anhydrous humor 😂
@@autisticguitar666 Give it a Google, you might laugh.
Clever.
"Anhydrous humour" nice one lol.
Only chemistry students will get it haha.
In the beginning of 2020, a large chunk of Rio de Janeiro's water supply was contaminated with geosmin due to an cyanobacteria* bloom in the Guandu river, from which most of Rio's water is pumped. There was nothing wrong with the water, it is obviously treated, but they couldn't remove all the geosmin, and since we can detect it in such small quantities, everyone's water tasted and smelled like dirt for some months. It still happens from time to time, but it usually lasts a few days, nothing compared to the almost three months (iirc) in 2020.
* Although Brazilian media just called it an algea bloom, cyanobacteria aren't algea.
Todo mundo gosta de água do filtro de barro, mas quando a água fica com gosto de barro todo mundo NOOOOOSA
@@abacaixi pior
hmm delicia agua com cheirinho de terra
You're telling me instead of synthesizing it we xan just get some algae to do it for us? Lol
was there ever a paper published about the type of algae??
As our Aussie friend always says, yellow chemistry is evil lol
And our Canadian friend says "I love urine chemistry!"
To be honest, I am really sick and tired of this. Yellow is just as good as the other colours of the rainbow.
@@crabcrab2024 yellow is a bad color🥶🥶🥶🥶🥶
Tar!
@@jaymzx0 Tar is dark-brown or black, not yellow)))
"In the end, I am left with.. YELLOW???" What a plot twist haha! Tom really did the chem community right with starting this trend
Chemtubers all watch each other and I am here for it
Wait can you explain the yellow trend and where it started?
@@hashimhassan4970 Extractions and Ire
@@hashimhassan4970 Tom from explosions and fire (and his secondary channel, extractions and ire) has a running gag of yellow = bad after having a terrible experience trying to make S4N4, pretty sure. Since then it's kind of picked up because most of the time something going yellow is a bad sign that something is degrading and tar is coming your way :)
@@gabepesco also Grimace isn't yellow.. Don't forget about Grimace now! The ol' goofy purple bastard!
Can’t get over how complicated this process is. In my college organic chemistry labs I’d manage to mess up a 3 step process, so seeing someone carry this out so perfectly is super impressive.
Yeah but the chemistry has been done before. A 3 step novel synthetic route can be far more challenging vs repeating known procedures
@zachliveris2881 you think they did novel synthetic routes in college ?
That's my favourite smell, along with the smell of pine trees and cool, brisk, fresh winter air, as well as burning wood. Just writing this brings back so many memories, it's surreal.
I feel like the morning summer air of the suburbs with all the pine bushes and trees, but here in Cali winter is the best if you have a clear nose cuz everything is blooming after rain
I wonder why the air on a crisp frosty winter morning has its own characteristic smell? What could the chemical composition be?
@@garycard1456 The chemical composition is 78.08% nitrogen, 20.95% oxygen, 0.93% argon, 0.04% carbon dioxide, small amounts of other gases, and 100% cold lol.
@@oitthegroit1297 sounds about right. checks out👍🏼👍🏼👍🏼
@@garycard1456 I always thought it was just the nose getting instantly runny causing the "smell", since it doesn't seem likely that there's anything special in the air during winter
Videos like this always make me appreciate the rotary evaporator we have in our lab.
you got any broken out-of-service units? asking for… a friend of course
@@AndyU96 they both accomplish the same thing except the vacuum distillation setup in the vid applies heat which can be bad if your compounds are sensitive to heat. But mostly cause it takes way less time to use a rotovap vs using vacuum distillation
@@AndyU96rotovap is faster and easier to get going.
As a preparative organic chemist I have to say, that is some quality work right here. Congrats to you my friend, I usually mess things up big time when trying to reproduce a paper for the first time :)
As a (former) synthetic chemist and longtime chemistry hobbyist, I concur! This is great work.
Regarding 13:23 - I'm sure you already know it, but for anyone who wonders: many organic stuff are yellow because they have a lot of conjugated bonds in them (in the case of the imine here the bezene ring is conjugated to the nitrogen via its free electron pairs). This causes the electronic excitation energy to drop, bringing it from the close UV range into the visible range, i.e. the molecule absorbs deep-blue/violet photons, and we're left with a yellowish-looking product. For green we would need to absorb in the visible range both blue and red, which is not very likely.
In addition, the aldol step at 15:45 tends to produce anything from yellow to orange, red, brown and tar -- at least on less, specific shall we say, substrates? Example, a similar reaction done with acetone leads to condensation products ranging from diacetone alcohol to mesitylene and relatives, and onward including indeterminate polymers. Fortunately, the molecule here reacts preferentially with itself in good yield.
A substance doesn’t really need to absorb the entire excess spectrum to produce a certain color as human vision cannot discern accurately between spectral colours and mixed colours. Instead, it’s more a complementary color thing where the absorption of a certain (narrow) spectrum makes you perceive the substance as the complementary color due to the absorbed spectrum being effectively subtracted from white (for the purposes of human vision at least).
For green, you’d “only” need to absorb in the red spectrum just like how most green plants do. The remaining “excess” blue and yellow adds up to green.
@@waterunderthebridge7950 good point
@@T3sl4 tar 🎉
You misspelled C U R S E D
Yellow chemistry :(
Geosmin :)
This was a fantastic video, the subtle humorous acknowledgment of frustrations among the otherwise professional depiction made me actually physically laugh during a chemistry video, bravo.
Oh yes, yellow chemistry at its finest.
Wow. The patience. The dedication. Not to mention the skill. Mad respect brother.
I love that there are smart people who are happy to share how smart they are, so I can look at all the squiggly diagrams and fancy equipment and feel like I got a tiny little bit smarter.
Thanks for taking the time to create, edit, and share.
Like NileRed, but with a 10x harder product and difficult process. Really interesting to watch, I had never heard of that chromotographic separation process before. I don't know how the closed captions work, but there were many inconsistencies between what was said and what was in the captions. Also, I caught at least one situation where your video text said 1% HCl and you said out loud 10% HCl. This is absolutely insane, and I would have loved to to get my hands on that and smell it.... spread it around the house... lol.
This video is more emotional to me for some reason
With a synthesis of so many steps and ever decreasing yields I'd be getting anxiety about having to repeat the whole process just to have enough material for the final steps. Amazing work!
"Oh wow, seems to be going good, glad he did it first tr-"
"I ADDED BROMINE"
What always amazes me is how mother nature creates the most complex molecules with ease (apparently). Just think of all the fruit flavors for example. And here, she just let's it rain on soil and voila... Petrichor. This makes me wonder if scientists have found out how this all is achieved (especially flavors) naturally.
if we knew everything, chemistry and biology as sciences wouldn't exist anymore
Fruit flavors are not that complex
I don't know if you did an QaA about this but I was curious about the way you keep up with the things you do in your life and the passion about chemistry? Do you work as an chemist or you keep up another type of work and you make these wonderful videos on your free time? How much did you spent from the start to this day on home chemistry? When and how did you study chemistry (i imagine moreover the school education)? Did someone inspired you? Did someone has incentivated you to pursue this passion at home? Did you received or do you ask for chemistry or practical help from someone? What do your friends or parents think about your passion? Whould you ever incentivate someone to follow this beautiful path which is chemistry and sperimental home chemistry? And do you consider yourself happy?
I hope you would answer these questions and remember that we're really happy to be your followers and that your's is one of the best chemistry channels here on the platform!!
This is such a weird coincidence, this morning while getting ready for work I saw I had a sample of 1% geosmin in triethyl citrate sitting on my shelf from years ago and decided to smell it only for you to post this later in the day. It’s a wonderful smell, but you’re right it can get overpowering very quickly. Great video!
I see explosions and fire is not alone in his opinions regarding yellow chemistry
So sad there is no more sample, I've almost touched by the tip of my fingers one of my dreams,. This fragrance is like smelling life, its really therapeutic for me, just few breathes of it and it's like a big calm ocean with blue clear sky, take place all over my inner self. No more knots in my guts. only feather-light state instead. This a definition of a really peacefull sent. Thank you and bravo to you dear Chemiolis.
Best chemistry youtuber on the platform, love all of your videos, always excited when a new one comes out. Keep up the great work
Pure Geosmin solutions are a part of many sensory kits!
At the food company I once worked at they did taste tests of some water samples. The testers were trained by drinking highly diluted chemicals such as Geosmin or DMS.
I have no clue what's happening or what he is doing but it's satisfying to see all that chemical work turn into something
One of your best videos,outstanding reactions and an unusual compound. Very nice of giving samples of product too!
Love laid back style of your commentary dude, makes this very enjoyable and approachable 😀
I LOVE the smell of petrichor! Gonna have to make it!
As an organic chemist I can tell you that this is some very nice work.
Very impressive. Congrats!
Your videos are always amazing, but this one is probably the best. Very well done! Keep it up :)
Ah now I get the smell referrence!
I am physics lover but now I can see my mind going in arms of chemistry.
This was an awesome video!! Thank you. I loved the chemistry, I loved the humor, just an all around perfect video.
I love the smell of rain right before it starts pouring down lol thanks for sharing
truly an underrated channel. Watching you make this was so interesting
Yes, make rain smell science man
So complicated that I lost track this time. 😵💫
It's a miracle that so much product could be obtained at all in the end.
Sending smell samples was invented by labcoatz - a good idea to profitably compensate for the missing sensory impression.
How about the sent of wet dog next time? 😉
I was always told the smell of rain was from O3 (rather than the regular O2 we breathe) but I never really looked into it! Thanks for the video
You DO smell ozone when there's a lot of static electricity, or very strongly directly after a lightning struck
Man I love the smell of ozone. Its like spicy air
hell yeah this is my type of 2 am content
I like to watch your videos when I'm tired and want to take a short nap in the armchair. I'm not a chemist, nor am I too interested in chemistry, but I enjoy listening and watching a bit of video until I fall asleep for a short time. 😃❤️
And of course Im always awake at the end to see the result!
Can we just appreciate how mother nature just does this naturally and so quickly. Thats insane!
I think another good reason to add athylene glycol during the bromination is to disfavour deprotection of the ketal, since that will also yield ethylene glycol (le Chatelier principle).
Oh yeah the deprotected one is probably a pretty strong lachrymator too lmao
That was a very technical and laborious process, and you crushed it! Good job
What an amazing synthesis. Congrats!! I cannot imagine the time all those steps took. Truly impressive.
Damn, that's impressive and awesome. You deserve to get a rotovap.
I mean, you also deserve an NMR and GCMS machines, but one step at a time ;)
Oh, a nice smell :). We all thought you were going to make some cursed tellurium compound or something lol
Your synthesis skills are impecable 😍
@Chemiolis - 2023-01-31
Finally it's here!! For full transparency, during one part of the project my SD card corrupted, causing me to lose some footage. Since I couldn't go back and redo it, I had to record staged footage and reuse older footage. So from 19:45 to 20:58 and 21:40 to 22:17 you see me re-enact what it looked like as closely as possible but without the product actually being there. Then from 20:59 to 21:39 I am reusing footage from before. Also, the structure of m-chloroperbenzoic acid at 17:44 is drawn wrong, it should be the meta isomer, not para. And I realized 'cyclisize' is not a word, I will use the excuse of not being a native speaker. Enjoy this 11 step synthesis!!
@ihateyou1379 - 2023-02-01
New minion movie looking good lol.
great work very impressive
@adrianpip2000 - 2023-02-02
Extremely cool multi-step synthesis! Not to mention that you did some high quality practical synthesis here. Also pretty cool that you're sending off samples to supporters. Would just like to add that it'd be nice to have some small text in the corner of the video when it's a re-enactement. Cheers!
@shiftgood - 2023-02-03
1ml of this sells for $360....
@joshuaosterhout - 2023-02-04
This content was super interesting, but it comes at you like a bullet train (no pauses). It can be a little disconcerting when you speed through 5 solid minutes of chemical names with no break in between.
@cas8891 - 2023-02-09
Are you by any chance dutch? I noticed a little bit after way too long but i did pick out a couple of pronunciations when i started to focus on it, and now you saying youre not a native speaker... That would be really cool! Anyways loved the video im glad i got it in my recommended im definately gonna binge you