TheHomeScientist - 2010-02-19
Forensic presumptive drug testing using Marquis Reagent and Mandelin Reagent to test various over-the-counter drugs. For more details, see: Color Test Reagents/Kits for Preliminary Identification of Drugs of Abuse http://www.ncjrs.gov/pdffiles1/nij/183258.pdf Viriginia Department of Forensic Science CONTROLLED SUBSTANCES PROCEDURES MANUAL http://www.dfs.virginia.gov/manuals/controlledSubstances/procedures/221-D100%20Controlled%20Substances%20Procedures%20Manual.pdf Mandelin Reagent 0.1 grams of ammonium metavanadate dissolved in 10 mL of concentrated sulfuric acid. Marquis Reagent 10 mL of concentrated sulfuric acid added to 0.5 mL of 37% formalin (formadehyde) solution. Substances tested: 1. Aspirin 2. Loperamide hydrochloride (Imodium antidiarrheal) 3. Chlorpheniramine maleate (allergy medication) 4. Loratidine (Claritin, allergy medication) 5. Diphenhydramine (Benedryl, allergy medication) 6. Meclizine (dramamine, antinausea medication)
as usual - top notch science here! thank you!
Would caffeine or theobromine give a positive reaction?
@bletnahuj That would (a) produce hot sulfuric acid fumes, and (b) cold sufuric acid is scary, hot sulfuric acid is terrifying. It's easier just to buy drain unblocker conc. sulfuric acid.
Во славу Токсы)))
good day sir! i was wondering where i could buy this marquis reagent because we were proposing to create an invention for our chemistry. we'll be using a nail polish with a marquis reagent as a drug detector. please reply as soon as you read this. thank you in advance.
very soothing watching this
@breathfire2001 Boil down some battery acid you can find at your local automotive supply store
Coach Smith
This is really good! I've made ammonium metavanadate yesterday and was looking for a good use. This is a great idea. I am really wondering about the chemistry behind these tests. Why do you get those specific colours? What happens?
This is possibly one of the best examples of how to perform a reagent test. on youtube or the internet. Great for people who did not have the pleasure of majoring in chemistry.
@TheHomeScientist Hey, was wondering if you can use the principal of the Marquis Reagent to detect Formaldehyde in a sample. For example, old insulation called UFFI contained formaldehyde. Could we add sulfuric acid and a drug and check for color? My point again is to find out weather the sample contains Formaldehyde... Thanks for your comments!
I like your way of thinking... even split bubble wrap. How big though the small or the larger bubbles?
Which color isn't intense?
Is it a problem if I test using impure, dilute, powdered mixtures of active drug in relatively much larger quantities of tablet excipients, do I need to beware of potentially 'false' colour changes due to various tablet coatings, fillers, colouring agents, etc. rather than the active ingredient itself? Thank you for the great video :-)
@TheHomeScientist Well, after some research, I know the Chen-Kao Test forms coloured chelate complexes with copper sulphate and Simons tests form complexes with [ONFe(CN)5]2- (nitroprussid-acetaldehyde I believe, a prussian blue derivative), So my guess is that the Mandelin reagent forms coordination complexes with vanadium. But I can't even guess how the Marquis works, because there is no d-block metal for coordination complexes in the reagent.
would this work with a urine sample,or would it be too dilute for this type of test. i think those types of tests(homekits) use some type of an antibody reaction.
Can you prepare your own Mecke reagent? i can't seem to find selenious acid or selenium dioxide. is it possible to a home scientist to get a hold of what is needed in Mecke?
cool video
anyone else here for there forensics class
This man sounds like a robot
Those colours were intense.
Nice
I have a question regarding your results. I believe you said that the Chlorpheniramine maleate sample provided inconclusive results with both wells, but at the end, the contents of the well turned a green color. Would you still record this as no reaction, and if so, why?
Marian Iranga Perera - 2013-08-24
Thank you,, :)