Corrosive Chemistry - 2020-07-14
The synthesis of the extremely bitter compound sucrose octaacetate from sucrose, sodium acetate, and acetic anhydride. The synthesis step of the procedure was trivial however getting the product to crystallize took a fair bit of trial and time. This video was on the shorter side due to the simple synthesis of the product. However as this was an end product with clear usefulness I thought it was worth making a video of. Let me know what you think of these shorter style videos! Patreon: https://www.patreon.com/corrosion Papers used: Cox, G. J., Ferguson, J. H., & Dodds, M. L. (1933). III. Technology of Sucrose Octaauml;cetate and Homologous Esters. Industrial & Engineering Chemistry, 25(9), 968–970. doi:10.1021/ie50285a006 Mann, T. D., Mosher, J. D., & Wood, W. F. (1992). Preparation of sucrose octaacetate—A bitter-tasting compound. Journal of Chemical Education, 69(8), 668. doi:10.1021/ed069p668
Talk louder (and maybe a slight bit faster) when recording your voice to get less of the "errrrr" type backing to it. Cool stuff though, i wish acetic anhydride was more available so i could try producing the substance myself
How does the apparatus at 4:18 work? I assume by context it is an old school melting point apparatus, but I've never seen it before!
It is called a Thiele tube. You can search it in google.
1:46 what is the thermometer model
Interesting video!
Make Denatonium benzoate and see how bitter it is.
you turn sweet into bitter!!
Nice synth
Corrosive Chemistry - 2020-07-14
For the product analysis I also tried running a couple TLC plates with various solvent mixtures, 1:1, 3:1, 16:1 hexanes/ethyl acetate and 3:7 acetonitrile and water, however, no spots showed up,. But the mp was quite good so I felt comfortable tasting the extremely small amount needed to detect the bitterness of the compound
adrianpip2000 - 2020-07-14
The reaction probably wouldn't create any conceivable toxic byproducts anyway, afaik. Kinda want to test this myself!