Apoptosis - 2024-03-18
In this video I demonstrate three ways of making the incredibly commonplace (but fairly tough to buy) chemical methylamine. I used the methylamine produced here to make a photographic developer called Metol, which I'll demonstrate in a future video. There are numerous other methods of making methylamine and its salts, as it is the simplest primary amine and a simple byproduct of a multitude of biological and organic decompositions, but I believe these three methods to be the most useful. This video was done on the behalf of several Patreon requests, and I am sorry it took so long. Hopefully it was worth the wait. Enjoy! Join this channel to get access to perks and support my work: https://www.youtube.com/channel/UCw8axYTp2BtinEmM_rdzUjQ/join Since this is my longest video to date, I made numerous mistakes in my Narration. Many I caught during editing, but I'm sure you all will catch many more in the coming days. So far it's been noted that: At 2:22 methylene imine is being reduced and formaldehyde is oxidized. Not water. Note that this video involves the use of dangerous chemicals, and generates toxic gases. Nothing seen here should be reproduced except by professionals or under professional supervision. Synthesis of this chemical may violate local law or ordinance depending on your country of residence, so always check before proceeding with any chemical procedure. Also note that I will not now or ever be using this chemical to further manufacture any chemical that is illegal in any country, so do not ask.
“To my other favorite W.W. It's an honor working with you. Fondly, G.B.”
Willy Wonka
@@Gelatinocyte2 Woodrow Wilson?
Walter White?
🙌 You got me!
@@superman9693 No... Wonder Woman.
Now I just need a lung cancer diagnosis and an RV
Gotta teach high school too
@@integral_chemistrygot tat. each highs chool too.
Stay out of my territory.
And work at a car wash
Hell yeah
Lets go mr White!
5:50 Safety advise: I learned (during my vocational training almost 45 years ago) never-ever to set "normal" Erlenmeyer-flasks or other glassware with straight walls under vacuum due to the danger of an implosion. Only glassware with thick walls or roundbottom flasks should used for work involving vacuum. Before starting to work with vacuum, roundbottom flasks should be examined thoroughly for the absense of cracks. Btw: excellent work!
Thank you so much! And thank you as well for the advice. I've never read about implosion under vacuum, but I have enough experience that I had a gut feeling it was a possibility. So far I've avoided it by never pulling anything near a full vacuum and compensating with higher heat. My biggest implosion concern is always the liebig condenser.. the inner wall looks very thin, but I do feel the geometry of it makes it less likely to undergo implosion.
What do you think? Is it mostly just a concern with erlenmeyer flasks?
@@integral_chemistry borosilicate is a relatively brittle glass, it just has low thermal expansion so its a lot safer to use in the thermally rambunctious setting of a laboratory. Under vacuum the glass would mostly be under compression, ergo depending on the vacuum level I dont see it as being much of an issue (again depending on the depth of the vacuum. There is a reason near perfect vacuum chambers where you cant suck molecules out anymore you have to hit them with something (ie, those super freaking cool oil vapor pumps, Ben on Applied Science has a video of a fully glass one in operation. its amazing) are made out of thick metals. The atmosphere does not have a sense of humor....).
That being said, Im not discounting the OPs experience in having glass implode under vacuum, just like with heat it can be hard to see the flaws that will make them fail. And I can absolutely see a regulator going screwy and pulling far too hard. Then all youd need is a cheap thin piece of glassware in the apparatus and its a afternoon of clean up, neutralizing, decontamination, and thinking up an excuse for the hospital burn ward (nosy bastards.....uh, or so ive been told). It sucks throwing away money like this, but take some time and test things to failure. If theyre only tested to some point, you have no idea how close that point is to the failure point. And besides, destruction makes for great (and informative) content ;)
Be safe, mate! I want to see more awesome videos!
One of the biggest problems where I live is they've made the glassware extremely difficult to get without having a legitimate job that requires you using them there's no retailers only wholesalers who won't sell to the general public plus it's a crime to have certain flasks without proving you have them for legitimate means
YEP! AS i SAID FOOLS FOLLOWING RECIPIES MAKE NOTHING BUT JUNK!
THEY JUST DIE TRYING!
WHICH IS LUCKY FOR US REAL CHEMISTS!
And where are you from, if i can ask? It's really irritating the degree at which basic science equipment (and I use that term loosely but really am just talking about your most basic lab supplies and chemicals) is being criminalized and kept out of reach from the majority in order to gate-keep, increase surveillence and the police state, and create an even wider skills gap between good paying jobs, science, and people who can fill those positions. I understand the need to monitor List 1 precursors, controlled substances, dangerous chemicals and posion, things that have no business being outside of a lab, large shipments and import/exports. The problem arises as those lists gradually grow larger each year and tighter restrictions are passed in such small increments that nobody notices until a back yard chemist has to start synthesizing more and more chemicals in unsafe equipment for 100% legal uses, when they otherwise would have bought safer equipment and starting materials. It doesn't solve anything and only creates problems. Because guess what? clandestine labs that manufacture illicit substances are still finding ways to operate, and are even creating new synthetic precursors and substituted derivatives. It doesn't take very long on Google to figure that out. And let's be honest here, addicts are some persistent mfers. If anything, those in the field right now, that have degrees and work in labs should be pushing back on some of these regulations. In the name of public interest, in the name of safety, in the name of freedom, in the name of science. I bet very few of us here would have too much in common except for one thing: the love of chemistry. That brings people together instead of the governments brillant idea to keep people apart. Just food for thought. @davemeads859
Edgy synthesis presented educationally!👍
Btw the thermometer-stirring is brutal!
Yeah I've been good about not doing it for several months now so watching it back in editing physically hurt me. Not looking forward to how many times I'm gonna get called out on that 😅
But thank you! "Edgy synth presented educationally" is exactly what I was going for. I think it is a really cool process from a scientific perspective, and so I wanted to show it without risking any flak from YouTube. I think it's delivery is so void of any drug glorification and dry enough that it should hold up.
As a side note I've been sitting on synthesis vids for TNT, RDX, and acetone peroxide for ages for the same reason I sat on this video for ages.
@@integral_chemistry Don't worry about the thermometer-stirring, we have all been there.
Those energetic material syntheses are as edgy if not more, it would be risky to be taken down somehow but that totally depends on the YT reviewer's decision (Which is rather inconsistent), I do think those rules are less strict than before as I can see some of those edgy videos resurfaced.
I would avoid the acteone peroxide. I never made it and still had the ATF on me about it.
@andrewbounds yeah thats the feeling I got.. I scrapped it and I guess I'll go ahead and toss the footage too 😅
I've always admired the historic chemists like Lavoisier and Davy and so many more. Like theirs, this chemistry explores new territory. You seem to already know far more about methylamine hydrochloride than does Wikipedia does about methylammonium chloride. Thank you for letting us observe your process so clearly.
Thank you so very much, it means a lot. I do try and be creative and informative in all my work, and I'm so happy it doesn't go unnoticed.
I want to see a future where amateur chemists just synthesize everything from air and seawater.
I just love the way you did the experiment Sir. The government watch list stuff is such a double edged sword. They tell you one thing and enforce the other. A double standard to say the least .
I mean, a “watch list” just means they watch it. Those chemicals aren’t illegal to possess, synthesize or distribute. Just don’t have any Sudafed in your medicine cabinet…
THAT IS A FACT FELLA. @@Sniperboy5551
@@Sniperboy5551actually the process makes no need for Sudafed. LoL but more money can be made selling purified chemicals than gold and oil combined
Just don't store intermediates, who knows what those watchlists test for. A innocent intermediate can get you in trouble. Always go through the process or at least have your work up papers handy for intentions
the government would hardly let you have water if they could get away with it.
During environmental engineering at university, around 2010, one of the compounds we had to make was methylamine. This video completely randomly came up which prompted me to find my old engineering biochem lab books. It contains an amazing amount methods to make some very interesting chemicals. Each method was done by prior PhD students and there was clearly a doe eyed lack scrutiny. Basically, a book of handwritten pre-cursers for the common man :D
could you please scan it or takes pictures of the pages? i want a copy please
Excellent production, Bravo Vince!
Blue, yellow, pink whatever man just keeping bringing me that.
Jessie we need to cook!!
TIGHT TIGHT TIGHT
Proud to be joining the watchlist with you all
Been on it for decades now 😂😂
I love when my favorite YouTube chemists make watchlist chemicals lol. The synthesis be looking so interesting but I won’t risk attempts at it myself because here in the states certain restricted chemicals are taken very seriously when manufactured or possessed. That’s what you guys are here for! ☺️👌🏼
I agree with that, this isn't something I'd ever do if I didn't have this whole channel to legitimize its synthesis. If I was just doing this as a small-scale hobby I'd never want this just lying around.. even though it's legal, the optics are bad.
YouTube has recommended a video on P2P purification to me… I just like watching chemistry
@@Sniperboy5551 that part! I’ve seen a few. I’ve literally seen the synthesis of methamphetamine base by the Lukehart reduction by a channel called TDC and it randomly popped up in my feed because of watching chemistry videos. 🤔🧐
@@integral_chemistryBro, have you ever made oxytocin? I'm very curious about this. How is it extracted from the ergot fungus? I really want to extract it myself. Can you teach me?
I think you can legally manufacture list chemicals for use in on going synthesis as long as you don't sell them
If only we knew what fascinates us the most at 2 years old y know even by 18 I’d put my life into learning about chemistry this stuff fascinates me AMAZING, INTERESTING , beyond bulk making dangerous stuff you should be allowed to make and experiment with crossing ,creating ,, tryjng and learning about whatever chemical you want to make without federal involvement or regulation. It’s disgusting to think you can get put in prison for 25 to life for accidentally or purposely making something to make something else. We need less regulations in chemistry since you are the ones at the cutting edge of all our technology. The true badasses are the chemistry students they are the ones making life better, safer , less painful , cleaner , healthier , more productive , you are the spear of human technological advancement in every way possible I admire anyone who chose this profession. I’d love to have nerd ass chemistry major friends man
But you guys are too busy making 456 k your first year you deserve it . Don’t go working for the DEA guys they pay the worse and you’de get bored quick looked down upon by other agents plus the principle of it. Battery technology , space materials , fuel technology
Colombian jungle process analysis
Or designer drug makers make double
all pay 500 k first year alone 1 mil last two as a dea chemist you’ll be making 220k after 20 yrs in and that is cap. Analyzing drugs so you can make them illegal before they are even created is just wrong goes against human progress. Never be afraid to advance chemistry in any way possible open up and try whatever you guys want to try tech , pharma , material , the chemistry majors of today shape the future tomorrow you chose the most meaningful carreer you ever could have as a human being !!
I'm not living in America, but I'll have fun watching this with my personal CIA agent at Pine Gap here in Australia 😂
If you ever want to pissed them off download the 10hr he-man hey yeah video, reencode it (so the file hash changes), name it something interesting like maybe a color with a type of dwelling followed by the thing we walk on and another word for an idea or Body Oder Mother Board (get it?), and reupload it. Some poor sod will have to sit through all 10hrs to make sure its clean ;)
@@TankR ?
@@ahmaudarberywasaviolentkle8094 What part are you confused on? The get a long video, ie he-man hey yeah, part, the name it something potentially of national security interest part, or the thus force an agent to watch 10 hours of hey yeah part because the video is just the original but reencoded so it wont match the hash of a known file part?
@@TankR too cryptic.
@@ahmaudarberywasaviolentkle8094 get some crayons and some paper, work through it. Youll get it, champ ;)
This was very detailed and informative great video man! My favorite method for this is methanol and sulfamic acid. Very cheap and very easy!
I was considering that one, still might do it at some point.
But thank you so much! This video took ages so I'm glad it's appreciated
Love increasing my inclusion on intelligence agency lists!
Same. I have another good channel if you want one
@@markymark-2 what the the name
iiiiii doooooo@@markymark-2
@@markymark-2 I want plz
@markbledsoe1664 yes please
My uncle used to make something like this in the trailer on the side of the house. He's in prison, but it seemed like he had a good time getting there. He really loves chemistry.
I saw something about a family member find. When my parents passed, they had a big brown glass jug of Chlordane. It took us quite a while to find someone who would take it.
Chlordane!!! Been a long time since I gave seen that name!
Excellent video, would love to see the reaaction with bromine
😂 great video! I’m never going to use this knowledge, but I love collecting dangerous information. This channel is perfect for that! I’m gonna watch your making TNT video next 👍. The commentary is good too! You are very easy to understand and explain it in a way where I know what’s happening at least. I only have taken like 3 chem classes in college and I can still get the gist of it. Subbed for sure! 👌
Thank you so much! These are my favorite type of comments, and I deeply appreciate hearing that some people get the things out of my work that I intended. Very happy to have you along :)
@@integral_chemistry No problem, thank you for the content! Have a great day 👍
0:11 it's also a rocket fuel, a dessert topping, a feminine hygiene spray, and a bumper polish.
It's so widely used it is frankly bizarre it is regulated the way it is.
I just discovered this channel, but I regularly watch multiple other chemistry channels and I have to say that this one really stands out (from what I’ve seen so far) in terms of the pacing and level of detail/explanation. While I certainly enjoy the other chemistry channels I follow (I mean, obviously, because why else would I continue watching them?), each of them is just slightly off from what would be ideal for me in one or both of those aforementioned aspects - a bit too high-level, a tad more assumed knowledge than I possess, a beat slower or faster paced than my attention span and mental processing are equipped to handle, you get the idea. But this channel has been almost perfectly in-tune with my preferences on all counts. I’ve been able to follow along in real-time (i.e. without the need to frequently pause/rewind, or else fail to retain certain details) with full comprehension, and at the same time there has been very little of the unnecessary or redundant information (again, for my level of knowledge and comprehension) that typically causes my mind to wander.
tl;dr - Cool channel bro.
Programmed cell death guy tells us alternatives to raiding a warehouse with thermite.
I will certainly not use this knowledge for evil…
these are all good reliable procedures, but my personal favourite, and one of the most efficient with least waste, is one I've not yet seen demonstrated on YouTube
it's the reduction of formaldoxime to methylamine; formaldoxime can be formed from the reaction between formaldehyde and hydroxylamine in basic conditions
It's an honour getting in the watchlist with you all
Your recrytalization videos are visual ASMR. More please.
"I do not know how to make methylamine. I usually just use the barrel with the bee on it"
That was the phenylacetic acid, not the methylamine
Still better than robbing a train.
God Bless You!
It is close to being the fountain of youth. One that should always be with our people in peace and in battle.
Awesome. Are you familiar with the sulfamic acid/methanol method?
Thank you! And yes I was actually considering adding that as a 4th method, but the length of the video would just have gotten far beyond what I'd wanna edit. I may do a part 2 with that method, paraformaldehyde, and possibly glycine decomposition because on paper that should work
@@integral_chemistry Please do! Love ur stuff m8, keep it up!
You could as show the 4 way. In old lexicon they wrote Methylamine can be made from Caffein and Bariumhydroxid. maybe Calciumhydroxid works too. Sounds easy.
Walter, You have the right to remain silent.
now i have a trusty base for a henry reaction!! Thanks brother
what is there a black cadillac on my door
Oh nice, Can you do how to make phenyl-2-Propanone? 😊😊😊
Bad things are not the worst things that can happen to us. Nothing is the worst thing that can happen to us!
You know the Buisness and I know the chemistry
This is really interesting. I'm glad you did it so I don't have to, you brave soul 😂 I would absolutely love to see how it turns out using bromine though
Super! Thank you very much!
Terima kasih!
Thank you! 😁
I robbed a train for this stuff and you're telling me I can just make it myself?
I'm intrigued brother. Good content education is key
Nice video! For the Hoffmann rearrangement, the methyl group is one of the worst migrating group in such reactions so I'm not surprised you're having a hard time with it. Bromine oxidation might be faster which could avoid competing side-reactions, but other than that I don't see how you could improve the migration of the methyl group just by using another oxidizer
Huh yeah I hadn't even considered that angle. My thinking was perhaps a calcium-methylamine complex or double-salt formation. I do agree though, at least in my own experience for this channel I've done a Hofmann rearrangement in making hydrazine and anthranilic acid, and they both worked very well and wete FAR less temperature sensitive.
The wild part is this exact synthesis was the very first Hofmann rearrangement, and the one the entire mechanism was based on (although I might need to fact check that)
Hey mate, the oxidation is occurring at the formaldehyde carbon. Great video.
Hello personal RCMP/NSA agent ! Hope you enjoyed the video too
RCMP what a joke.
Canaduh is junkies holes
Thank you for being very informative and giv8ng a great step by step on your chemistry.
Jesse, it’s time to cook Jesse
LOVE ITTTTT!!
That train theft in breaking bad was about $300 million. Biggest heist ever
@nenben8759 - 2024-03-18
I love lists!
To-do lists, check lists, grocery lists, watch lists,
they're all great!
@TasPapadopoulos - 2024-11-27
😊
@Anonymous.530 - 2025-02-17
😂