Reactions - 2025-01-22
In 1998, a pharmaceutical company suddenly lost the ability to make their lifesaving HIV drug at one of its production facilities. Then that failure spread to the company’s analysis labs. Then it spread to the other production facility, and within months the lifesaving drug had effectively vanished from the entire planet. And this wasn’t the first time something like this had happened. How does a chemical just… disappear? #chemistry #medicine #crystallization #ritonavir Producers: Andrew Sobey Elaine Seward Darren Weaver Writer: George Zaidan Hosts: George Zaidan Executive Producer: Matthew Radcliff Scientific Consultants: Stephen R. Byrn, Ph. D Leila Duman, Ph.D. Brianne Raccor, Ph.D. Executive in Charge for PBS: Maribel Lopez Director of Programming for PBS: Gabrielle Ewing Assistant Director of Programming for PBS: John Campbell Reactions is a production of the American Chemical Society. © 2024 American Chemical Society. All rights reserved. Sources: Ritonavir https://www.chemistryworld.com/podcasts/ritonavir/4011593.article Ritonavir: An Extraordinary Example of Conformational Polymorphism https://link.springer.com/article/10.1023/A:1011052932607 Dealing with the Impact of Ritonavir Polymorphs on the Late Stages of Bulk Drug Process Development https://pubs.acs.org/doi/10.1021/op000023y Molecular, Solid-State and Surface Structures of the Conformational Polymorphic Forms of Ritonavir in Relation to their Physicochemical Properties | Pharmaceutical Research https://link.springer.com/article/10.1007/s11095-021-03048-2 Ritonavir Form III: A New Polymorph After 24 Years https://jpharmsci.org/article/S0022-3549(22)00428-2/fulltext Supersaturation Tower https://www.flinnsci.com/api/library/Download/c931fa405d384d77a06086654faa8ba2 (IUCr) Why don't we find more polymorphs? https://journals.iucr.org/b/issues/2013/04/00/bm5061/index.html Facts and fictions about polymorphism https://pubs.rsc.org/en/content/articlelanding/2015/cs/c5cs00227c Disappearing Polymorphs Revisited https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201410356 NORVIR Update https://www.natap.org/1998/norvirupdate.html Polymorphism & Seeding: II. Case Studies http://pd.chem.ucl.ac.uk/pdnn/mod3/polycase.htm Ritonavir: The Polymorph That Revolutionized Drug https://solitekpharma.com/ritonavir-how-the-discovery-of-a-new-polymorph-changed-drug-development-forever/ Disappearing Polymorphs https://pubs.acs.org/doi/abs/10.1021/ar00052a005 The Predictably Elusive Form II of Aspirin https://pubs.acs.org/doi/10.1021/ja056455b Crystal Polymorphism in Chemical Process Development https://www.annualreviews.org/content/journals/10.1146/annurev-chembioeng-061010-114224 Open questions in organic crystal polymorphism https://www.nature.com/articles/s42004-020-00388-9 Microgravity https://www.nasa.gov/wp-content/uploads/2009/07/315959main_Microgravity_Microscopic_Observation.pdf Tips for Taking RTV https://www.natap.org/1998/k.htm The Best Way to Temper Chocolate https://www.seriouseats.com/the-food-lab-best-way-to-temper-chocolate Compound Interest: The Polymorphs of Chocolate https://www.compoundchem.com/2014/04/19/the-polymorphs-of-chocolate/ How many more polymorphs of ROY remain undiscovered https://pubs.rsc.org/en/content/articlelanding/2022/sc/d1sc06074k Ostwald Rule of Stages─Myth or Reality? https://pubs.acs.org/doi/10.1021/acs.cgd.2c00141 How to Grow Sodium Acetate Crystals https://www.youtube.com/watch?v=2FqlAtWN2vo Supersaturated Sodium Acetate Crystallization https://www.youtube.com/watch?v=nrmQBdYp5tU Crystallization.ram https://www.youtube.com/watch?v=HoMLXFHylt8 Crystallization by Antisolvent Addition and Cooling https://www.intechopen.com/chapters/39142 Effect of ultrasound on the kinetics of anti-solvent crystallization of sucrose https://www.sciencedirect.com/science/article/pii/S1350417721004284 Ritonavir Form III: A Coincidental Concurrent Discovery https://pubs.acs.org/doi/10.1021/acs.cgd.2c01017 The History of HIV Treatment: Antiretroviral Therapy and More https://www.webmd.com/hiv-aids/hiv-treatment-history Recrystallization and Melting Point Analysis https://www.youtube.com/watch?v=iIfmoD-G1qo Crystallization of Sodium Acetate from a Supersaturated Solution https://chem.libretexts.org/Ancillary_Materials/Demos_Techniques_and_Experiments/Lecture_Demonstrations/Crystallization_of_Sodium_Acetate_from_a_Supersaturated_Solution_(Demo) Ritonavir: The Polymorph That Revolutionized Drug https://solitekpharma.com/ritonavir-how-the-discovery-of-a-new-polymorph-changed-drug-development-forever/ Combined crystal structure prediction and high-pressure crystallization in rational pharmaceutical polymorph screening https://www.nature.com/articles/ncomms8793 Inconvenient Truths about Solid Form Landscapes Revealed in the Polymorphs and Hydrates of Gandotinib https://pubs.acs.org/doi/10.1021/acs.cgd.9b00162
This is the chemistry equivalent of having your code working, accidentally breaking the project, rolling back to a working version, and then still having the same error message.
Because the error caused by something in cache 😂
And in both cases the reason is that you changed the environment
Imagine you need a drug to live and suddenly no one can make it anymore because all known batches of it turned into goop overnight, and now the reaction to make it just makes goop.
Already 139 years ago Dr Jekyll had a similar problem. Same chemical but failure to work.
the devs patched our exploit
Or the government puts a probation on it even though you can grow it yourself yeah it sucks
@@Altair4611 damn my cheat code that heal people to full health was patched.
@@KallePihlajasaari A missing impurity was his final thought, but it easily could've been the polymorphic switch, yes.
Chemistry was well studied but has advanced by massive leaps since.
I am a pharmacist and worked in the HIV clinic. I remember being told that RTV was no longer available as a capsule and only the liquid was available. Patients hated it. We weren't told why, just that production issues were the cause. Now, many decades later, I learn why. Thanks for the information.
Science not faith, Oh believe me it's a bit of both there is no getting around that one.🙏🏻😉🕊️🙏🏻
Remember the FDA recall of OTC l tryptophan? Manufacturer issue that was caught too late, for those who developed eosinopholia.
@@crimestoppers1877 But it WAS caught. With Trump, even if caught early, it won't be published or acted upon.
@@secretwatcher9922 considering the majority of scientists are intelligent and thus atheist, pretty sure it's all science👍
@@RobertRedland equating a lack of theological conviction to intelligence is such a fedora tipping atheist move
"hired a new student by phone, prohibited her from visiting the old lab or meeting anyone from the old lab, had her go buy all new glassware..." today this would be the start of a "fake job bad check" scam
For real. Back then things were more real
Sounds that she at least worked at the new lab building but solo as they ran the test lol
Also sounds like the beginning of a new horror game
So many red flags
And that is how meth labs are started😂
I work as a chemist for a large pharmaceutical company and we had a very similar case just a couple of years ago. Once we had the wrong polymer we had to switch buildings, technicians and everything... No glassware, no nothing was allowed to go in the other labs. I still think it is strange with all the hygiene and safety that there were particles somewhere in the air out wherever that caused every crystallization to produce the wrong form afterwards
Wow
Did the switch of place and hardware fix it?
The Andromeda Strain.
Rupert
I guess that's when people start believing in imprinted information, informed water and similar concepts.
Beyond fascinating. Those scientists probably lost their minds trying to figure it out. This is one of the best spooky stories I've ever hear.
I'm sure they knew what the problem was, but overestimated their decontamination procedures and didn't think it was a big deal until everything had been contaminated.
As a scientist, this scared me so much. I had never heard of something like this before in real life. It's like Ice IX or gray goo but only for a certain drug.
So what your saying is that this thing started reacting in a way we didn't expect, on it's own, without any outside intervention?
I'm no chemist but that does sound very worrying.
Corporation discovered a better way to make money off the problem and sabotaged production. Scientists were paid off or simply not told.
@wrongthinker843 plz stop.
I'm a Ph.D. synthetic chemist and I remember when this happened to ritonavir (I was a graduate student at the time). I later worked for a CRO (contract research organization) who had people entirely dedicated to polymorphs - deliberately trying to induce different polymorphs of drug candidates - to attempt to front-load this sort of problem.
I'm not sure I like the comparison of charcoal to diamond, as allotropes are covalent bonds. When I saw that I immediately began to think of chocolate as an example most people are familiar with - and then you went there.
@peterectasy2957 Nothing in the universe is completely insoluble, but for literally all practical purposes they might as well be
He did it right at the end comparing graphite and diamond.
From a semiconductor background I often had to make up comparisons to explain issues to non technical employees. On the spot I might have used a similar analogy even though there are better ones. I think it was a good way to explain it to everyone. Lots of non engineers would not know the structure of charcoal vs graphite. Just last month I had to tell a new technician that graphite lubricant was a dry powder. I first used it when I was 5-6, so that shocked me.
@@Mr.MashenIt That example's a simile
as a college dropout, I completely agree
as a college dropout, I completely agree
Hi there! I'm a synthesis chemist technician working in the exact same plan in Italy where the production of ritonavir took place. Well, at least while it lasted 😂 last year we attended a seminar/course on polymorphism by our lead solid state expert, explaining and telling us this whole story, from start to finish, and all the troubles and infinite headaches that this situation brought upon our company 😅 really interesting indeed how such a small change in crystallization can bring so widely different results.
If you have any questions or curiosities i can answer feel free to ask!
(Company name was Zach - Zambon Chemicals, but now the same production plan here in Italy is owned by FIS - Fabbrica Italiana Sintetici) 😁
Just commenting to bump your comment up so more people see it 🧑🔬💊💗
what steps did the company make sure in the new lab that seed wouldn't get into?😅
@@stefanradojkovic3585 Do you still manufacture other substances in your lab?
@@ElizabethVass oooh yes I would love to know this too!!
❤❤❤
Excellent presentation. I'm a Ph.D. analytical chemist with 30+ years of experience. I knew about polymorphs and their importance in the pharmaceutical industry, but was unaware of the ritonavir connection. Thank you for another excellent show.
I just love to hear professionals approved content. I am in a whole other field but had to look into chemistry in a project. I just love when concepts are explained clearly with examples. I first registered what devastating effects the chirality of a molecule can have after reading about the background of Thalidomid than could transform itself into its dangerous form after production.
You claim to know the importance of polymorphs in pharmaceutical synthesis yet profess ignorance of what is likely the most well known story about polymorphs in the history of pharmaceuticals. Chemist, analyze thyself.
the connection to paxlo and vid is not interesting?
@@amarissimus29regretfully I was thinking the same.
@@SixOhFiveYou guys are insane. You don't have to know one niche case in a completely different industry in order to be good at your own industry. But whatever makes you guys feel better about yourselves in your moms' basements.
I had no intention of watching this video, I am not a chemist, but your presentation was so captivating, I watched it. Fascinating!
Thank you!
Knowing a bit of everything is always good - we just have to make sure we do not suddenly believe that we know everything because of it.
@@Nick1979BN True! And no worries, I hardly think I know much about many subfields in mechanical engineering and I have a PhD in it. Let alone of the topics I have only superficially studied, like other fields of science etc. I think I know enough thats it's fun to listen to the real experts and it helps me contextualize - thats about it.
I had heard a similar story/urban legend about glycerin in the game "999: Nine Hours, Nine Persons, Nine Doors" and I thought it had to be completely made up. Apparently that specific case was somewhat overblown over the years, but it's WILD to me that the whole "crystal virus" incident is something that actually happens in real life. Incredibly fascinating stuff.
Right?! It blew my mind too!
Was literally thinking the same thing.
I remember a long section on Glycerin and crystalline forms of ice in that game.
Apparently it happened with glycerin in a manga called Baki, also. Glycerin can be crystallized under specific conditions to purify it
Part of what made 999 so enjoyable was how they mixed juuuust enough reality into their scifi BS that if you looked something up and saw actual legitimate science papers on something like it at a glance you will instantly buy in to everything and it feels INTENSE. It's basically the second best form of sci fi after hard sci fi, making it so believable that it doesn't matter how true it is because you can EASILY suspend disbelief enough to get totally sucked in.
ZERO ESCAPE MENTIONED
Great video, but my heart hurts for the countless HIV+ people who suffered while this was all going on.
Wow this is so fascinating. As a biologist it reminds me of prions. Just the presence of that misfolded structure infecting all other molecules and then causing them to switch to confirmation 2 as well, makign them so infectioud that just powder of it on peoples clothes could infect another facility and ruind their entire batch.
I was thinking the same thing. It would be interesting to compare both to get to know more about how they work
I do think self assembly is involved in it. Minimizing Gibbs free energy is mostly what is involved (95% of the time in the context of co-crystals on the CSD). But as there are those 5% missing, I think there is some new science there. I would like to maybe explain that paper in the future. But sincerely I can't procrastinate my actual research project that much...
The CSD is a, mostly organic, crystal structure database that is used by the small molecule crystallography research community BTW.
So the plot to Ice-IX came true in a specific instance. Terrifying.
That's what came to my mind.
Kurt Vonnegut's Cat's Cradle it a very good example of the sort of Science Fiction Horror you get out of an Engineer/Technical Writer.
@ Less center stage would also be the Strange matter cascade from Ender's Game.
@@kevinireland8020 It reminded me of the vacuum metastability hypothesis. There's a chance this could happen to the entire universe. It is untested, for obvious reasons.
Exactly what I was gonna say. Was looking for the comment. Cat's Cradle IRL.
I’m going to study chemistry at uni but am currently on a gap year and doubting why I even picked chemistry in the first place. Thank you for reminding me how great chemistry
rip
what we wish for: atago grade a calibration sucrose 20% (±1%)
what we get: bekes plaszt kft leftover sucrose (expired in 2012)
chemistry doesn’t go out of date.
Yoooo I'm split between going to pharmaceutical science and chemistry with a focus on pharmaceuticals do you have any advice?
I have bachelor degree in chemistry, i think right now its better to take food technology not food science or Biochemistry or biotechnology and perhaps pharmacy instead of chemistry, the job market is hard now for chemist
As a process chemist who has spent hours learning about how to run crystallisations, this was a great introduction to the topic!
There is a Sci-fi novel, in which scientists found a script encoded in a cosmic background radiation. After laborious analysis they found it contains perfect description of all laws of physics - all we knew, and more, which opened a door to rapid technological progress with inventions bordering magic. But at some point some of these inventions - in few cases right after first use, just stopped working, and it was later discovered, relevant sections in the script were just gone. Something was actively monitoring and modifying universe to restrict humanity.
This novel instantly came to my mind when you mention it couldn't be made anymore, followed by "aaah, contamination.".
What was it called?
@@usr01 I tried to search for it but the closest thing I got is The Three-Body Problem
Also a really good book @pyroblasted
please @ me when u find
@pyroblasted The general idea of his comment does seem similar to the TBP. An excellent read I can recommend to everybody interested in sci-fi
So this video made me realize over and over again that real chemistry is crazier than any sci-fi stuff you see in Hollywood.
One of the best videos I’ve seen on YouTube. Informative, educational, and even entertaining! Information is presented at a perfect pace! Not too fast; not too slow.
Kinda like when I don’t clean out the plaster/drywall completely from the mixing pan. Leftover gypsum crystals like can ruin your mix because it sets too fast. Catalyze the “set”.
I put my drywall into a portable electric wine cooler and scoop it out of there. Lasts for hours at a time!
Oh wow! Had no idea!
I really didn't know about polymorphs but this video made things CRYSTAL clear...
🗣BOOOOOOO
Your mind is now type 2 and this will not change.
😂
Golf clap
👏
Had this happen in a lab I worked. For months, a catalyst was a viscous liquid when purified. One day, it decided to ba a solid, and every prep thereafter was a crystalline solid.
Can't believe you did not draw the parallel to prions.
As a completely non chemistry person, I had the same thought, solely because of that mobile game plague inc.
That was the first thing I thought!
Chemically is there actually even a difference? Chemically proteins are just really big molecules...
Nightmare proteins.
The effect of prions in a general sense might be close, as you and I understand it; but what about all the folding of proteins, done incessantly in eukaryotic cells' endoplasmic reticulum? And 'denaturing proteins', like when you cook an 🥚 egg?
That would be another video I would watch, explaining the similarities and differences of these 4 + whatever else similar phenomena ...
I don't know why I watched this, I know damn near nothing about chemistry or anything, but this video came across as interesting to me. I understood 9/10 words in the video. Glad I went out of my way at 1:47 am to watch this. Good stuff.
😂😂 I know, same here! 🤣 Don't know why I watched it, don't know why it showed up in my algorithm. 🤷🏼♀️🤷🏼♀️ But it is very interesting.
Thank bill gates guys
Gen Z?
@@crimestoppers1877 perhaps, but some of this concepts are things I only learned until I went to college for STEM like activation energy shown at 7:04
Please write in two words what happens in this video ❤
I hated chemistry when I was in school as I never could wrap my head around it - I have profound respect for those who understand and master it. Generally I stay away from things that involve chemistry (specially youtube videos, etc...) - but this video had me hooked from the begining to the end and even thought me something I never imagined to learn. It was informative and entertaining. Thank you very much!
I will say that chemistry can be significantly easier to understand based on who your teacher is. I’ll give myself as an example. My first two years of college I was a life science major. Meaning I had to take Chemistry one and two. Chemistry one I had a professor whose teaching style did not mesh with how I learn best so I struggled and I almost failed the course. The next semester I had a different professor and it was night and day. Suddenly everything made sense and I got a B+ in the class that semester. Not to sound all preachy and stuff but science like chemistry is so fascinating for anyone beyond what is common knowledge and especially now there are so many you tube channels where you can see just how interesting it is. Juts because you struggle with w topic now, doesn’t mean you will forever and it doesn’t mean you should be unwilling to learn.
Me too
I love my algorithm. Thank you, not a chemist or anything close here and I actually understood 98% of the video. SUPER interesting.
That's a real clear explanation, wish I had you as a chemical teacher back in the days
I heard about this somewhat recently but this really made it much easier to understand the concept of polymorphs than the last way I learned about it. Chemistry is really cool.
Throughout the video, I could not stop whispering "ice nine!" The minute you said their other lab developed the same problem after they visited, it was immediately clear to me they carried in a microscopic contaminant. It's amazing how small a crystal can grow more of itself. (we used to do this in high school chemistry class)
Has there ever been any verified tangible evidence of this purported microscopic crystal? There are presumptions in the argument. "Well it had to come from somewhere!". Did it?
@@patrickmcshea5398 All it would take is something the size of a spec of dust. While it's possible it was spontaneous just like the other facility, the fact they'd visited from the other factory strongly suggests contamination. (esp. since this sort of thing has happened before)
Ha ha kurt vonnegut Jr. I forgot about cats cradle!
@ All you provided was a claim that something happened before. That's not evidence.
@@patrickmcshea5398 That's all ANYONE can provide. Can you find a specific spec of dust in your house? How about in a 100,000sq.ft facility? That's all it would take. Once it's there [and detectable], all your equipment is contaminated. Made even worse by the it not being water soluble.
While it's certainly possible for the events that caused type II to form at the first lab to also happen at the second, the fact that it happened after people from the first lab visited cannot be ignored, esp. when this very same type of thing has happened in other labs.
First time i watch a video of yours. Incredible editing and story telling. Not usually the type of video I watch and still stayed until the very end!
I saw a video about the Ritonavir "incident" some months ago but ... OK it explained a problem with crystals. But not how or why...
You did an awesome job !
the flow in this video is amazing
Me going to bed 1am in the UK.. detouring via random chemistry video in my feed. So still awake, watching it, learning things I didn't know I wanted to learn.
I heard this story on another channel somewhat recently and find it so fascinating! Love seeing the demos here. One of the most wild lessons in unknown unknowns.
I think it was Asianometry who covered it before.
@@Bearsinspaze YES! That's it! Another great channel.
That was something I never heard about, explained with so much clarity and interest! I immediately liked and subscribed.
Wonderful video , I’m an electrician , I know almost no chemistry , I love this channel and wish it had more subscribers , keep up the great work
electrican gang
Thanks and welcome!!
Remember that commercial space capsule that was stuck in space for about a year longer than the company wanted last year because they neglected to ask the FAA for a reentry license before launching? The one from Varda Space that had camera on board, whose video of the full reentry sequence over Utah went semi-viral ("Varda capsule reentry - full video")? Guess what drug it was autonomously synthesizing on-board in microgravity to determine the effects on its various polymorphs.....
Ritonavir.
Form III to be precise.
Nerds
'Space' belief? Demonstrate me two opposing pressure systems without a barrier between them. Go!
@@vthomas375walk up a mountain with a barometer. You'll find the pressure lessens with no barrier as you get higher.
Interesting. I’ve been on Ritonavir as part of my medications a while ago. I’m now in Dovato now and can safely say I never saw it as a gel capsule. It was part of a multi-drug tablet. That was a solid. I think that was the Truvada.
Interesting! Abbott reformulated Ritonavir an extra time (which we omitted from the video) between when it went back on the market as Form II and when the amorphous form was introduced, so it might have been that! Or maybe the amorphous form.
It is a VERY OLD medication, especially bad for you because it is a protease inhibitor, the ones with the worst long term side effects. It was used as a booster for other PIs up until 2010. Be lucky you never had them. Nowadays they are reserved for worst case scenarios, and ultra short treatments before switching to newer kind of medications (modern PIs are very mutation resistant and have a super fast mode of clearing out HIV, almost within days, but the lomg side effects are horrendous, fat redistribution, gynecomastia, etc. They are only employed if you already are so low ON CD4 cell count that you're clinically have AIDS). The modern medications have no noticeable side effects for most people, being usually Truvada and some ultra new fancy integrase inhibitor all in one single pill a day that is half the size of most vitamin pills or the Melatonin chew tables people take 😂
@ well, I remember my doctor trying to cover up the kidney function loss he’d caused with leaving me on the wrong medications four years ago. I now keep a very close eye on what they do to me.
Truvada is not Ritonavir. It's Tenofovir. Combined with Emtricitabine. I'm prescribed Truvada still (the generic version, as PrEP).
@@Jenny_Digitalif you're on truvada you could ask to switch to descovy as it has better kidney side effects but is otherwise the same
1:40 Sounds like a inside job 😂😂😂
This is such a good video for teaching polymorphs, thank you
This is your best video. My colleagues and I are using it our lectures now (with proper citations). Thanks for making it!
They ice-nine'd themselves.
I came here to make the same comment! 🤣
Kudos for the Kurt Vonnegut reference!
Bokonism. Tsk tsk tsk
I did make the same comment!
@@GeeTrieste Guess that makes us... nine!
This makes me think of polywater. Apparently some people thought it might cause the oceans to convert to polywater. Turns out it was just contaminated water.
if water was that unstable it would have done that millions of years ago.
Yeah, both this story and the polywater story are complete Ice-Nine scenarios.
(If you don't understand, go read a book called Cat's Cradle. Ice-Nine is not the same as Ice IX)
@@andrewdreasler428 how so?
"This is a reference to a telivision show called, The Office."
Gave me a good chuckle
Wonderfully informative
My god, that was incredibly fascinating! Im not a chemistry person so I appreciated the slow walking and humor. Surprised Ive never come across this information before!
You guys do such a great job. I’ll admit I’m a chemist nerd but your presentations are amazing. I’m a novice pyrotechnic ( supervised by the WPA ). The video on color was insightful and a follow on with the colors of burning salts would be cool. Also one on explosives vs high explosives. Like compounds that explode vs detonate.
This was a brilliant format. I struggle with the understanding of chemistry intellectually, but this was beautifully done! The story, the build up, the synopsis. It was very enjoyable. Thank you!
Us at Varda Space found a form III of ritonavir coincidentally with a group from university of Wisconsin - crazy that a drug with so much history is still has surprises in store. Quite the example of the importance of polymorph screening and control!
As an aside I have no idea why the Tolkien estate never sued you or Palantir.
I absolutely loved your voice and the way you explain things! You make complex topics feel so simple and easy to understand. Really great work!
@RealityMeltdownx2 - 2025-01-22
4:47 Wasnt that an "Office Space" reference and not "The Office"?
@mitchv.7492 - 2025-01-22
Exactly
@ACSReactions - 2025-01-22
No no, you've got it mixed up, Office Space is the one where Lumbergh keeps putting Milton's stapler in Jello.
@mitchv.7492 - 2025-01-22
@@ACSReactions Nice try
@swill128 - 2025-01-22
@@ACSReactionsyou're making form 2 crystals in my brain with that comment
@ediseverywhere - 2025-01-22
@@ACSReactions I thought Office Space was the one where the gang writes a program to rip off Weyland-Yutani but gets caught because they were off by a decimal place.