Synthesis Workshop: Demystifying the Soai Reaction with Dr. Soumitra Athavale (Episode 47)

Synthesis Workshop Videos - 2021-02-27

In this Research Spotlight episode, we are joined by Dr. Soumitra Athavale, who takes us through his work on the Soai reaction.

Parent reference:
Athavale, S. V.; Simon, A.; Houk, K. N.; Denmark, S. E.; Nat. Chem. 2020, 12 , 412-423. 

Other references (in order of appearance):
For a masterful commentary on this subject, see Mislow, K., Collect. Czech. Chem. Commun., 2003, 68, 849.
First kinetic formulation: Frank, F., Biochim. Biophys. Acta., 1953, 11, 459.
Soai Reaction: Soai, K., Kawasaki, T. & Matsumoto, A. Acc. Chem. Res. 2014, 47, 3643-3654.
Non-Linear Asymmetric Catalysis: Satyanarayana, T., Abraham, S. & Kagan, H. B Angew. Chem. Int. Ed. 2009, 48, 456-494. 
Sato, I.; Urabe, H.; Ishiguro, S.; Shibata, T.; Soai, K., Angew. Chem. Int. Ed. 2003, 42, 315.
Singleton, D. A., Vo, L. K..; Org. Lett. 2003, 5, 4337-4339.
Kawasaki, T.; Matsumura, Y.; Tsutsumi, T.; Suzuki, K.; Ito, M.; Soai, K., Science 2009, 324, 492.
Klankermayer, J., Gridnev, I. D., Brown, J. M.; Chem. Commun. 2007, 3151-3153.
Quaranta, M., Gehring, T., Odell, B., Brown, J. M.,  Blackmond, D. G.; J. Am. Chem. Soc. 2010, 132, 15104-15107.
Matsumoto, A.; Abe, T.; Hara, A.; Tobita, T.; Sasagawa, T.; Kawasaki, T.; Soai, K. Angew. Chem. Int. Ed. 2015, 54, 15219
Athavale, S. V.; Simon, A.; Houk, K. N.; Denmark, S. E.; Nat. Chem. 2020, 12 , 412-423
Athavale, S. V.; Simon, A.; Houk, K. N.; Denmark, S. E.; J. Am. Chem. Soc. 2020, 142, 18387-18406