Chemiolis - 2023-11-15
Check out the IKA Electrasyn 2.0 via: https://www.ika.com/en #electrasyn (sponsored) In this video I am showing a typical procedure for how to conduct synthetic organic electrochemistry, using the Electrasyn. It shows that it is a lot easier, safer and more convenient than regular organic chemistry where dangerous and more expensive reagents are required. It is also more atom-economic and reduces the amount of steps. This video was sponsored by IKA. It contains a product placement for the Electrasyn 2.0. The Electrasyn 2.0, electrodes and reagents were provided by IKA. IKA had no role in the production of this video nor influenced what I said. Don't conduct any chemical reactions without proper and professional safety analysis and risk management. Measures taken can be invisible, not filmed, not properly visible on camera or misjudged by the viewer due to setup or video construction. Always conduct own appropriate measures regardless of video setup.
Bro literally combined the two worst types of chemistry in existence and got an actual, measurable yield which is really impressive
He brooo where is your biodiesel video. Can you make it using coconut oil? I think the biodiesel will be great because coconut oil has many short chain fatty acids which might give a biodiesel with lower flash point and lesser viscosity 😉😙
How dare you, lol
Organic chemistry is the best type of chemistry, fym
Still kinda yellow
Dude. Ochem will always be supreme.
You’re basically the only organic chemist on YouTube who still makes legitimate chemistry videos! Please keep it up, your content is amazing!
There's one other gentleman that does great videos . Poor mans chemist is the channel .
Worth watching
I am so happy to see a video regarding my field of research!
Just to make it clear the Electrasyn is not the best set up to start synth. electro organic synthesis. There is a lot of literature regarding galvanostatic reactions from other groups only using a lab power supply and simple electrodes. I would be super happy to see more of electrosynthesis videos on your channel. You could contact me for some easy synthetic procedures or literature to show on your channel!
I’m looking into doing some electrowinning soon. For organic electro, I might do it again if it is necessary/convenient. It can be a bit limiting in scale sometimes.
Yes I know. Especially when using the screening kits like the Electrasyn etc from IKA. There are reactions known working in larger scale and easy work up procedure. I was involved in some multi gram scale up. Sometimes flow can solve this limitation.
How does microwave hydro diffusion come into play here?
i love that under everyone of these obscure videos there is someone doing a PhD in that topic that is obviously procrastinating on their thesis(looking at you Tom)
Your generation has the worst narcissism where you need to interject things that have nothing to do with this, while telling us how intelligent you think you are then tell him how super happy you would be to see more videos then tell him to contact you so his videos get made how you think they should.... you are a zoomer, or millennial.... I can tell
Reject complicated organic catalysts, embrace electrons
Electro organic chemistry sounds fascinating and all, but what really blew my mind in that video was this showerhead funnel you used to fill your column with solvent at 8:00 .
I haven't run a column in 8 years but where was this piece of glassware when I did? I've never seen this anywhere. Our glassblowers could have easily made this. I feel like i missed out on something important.
Always improving brother! Good video! Also this is black magic
I've been saying this for years, electrolysis for REDOX reactions makes so much more sense from an energy input standpoint and removes the need for high activity reagents. Only issue to be worked out for manipulation of organic compounds is finding a suitable polar solvent. Changing the anode/cathode material may allow for more selective reactions, i.e. partial reduction and targeting certain functional groups of a molecule.
This kind of chemistry is incredibly exciting. Can’t wait to see how it evolves and grows
Organic electrochemist right here! Great video. I use electrasyn quite often and can say it changes the game for good. Electrochemistry introduces more variables besides that of organic chemistry, which can be a nightmare for some but also an advantage as you can get different outcomes from the pure electrochemical optimization. Gladly electrasyn handles that very well and not much electrochemistry is required for one to get to know the field
This made my day! Please don't stop uploading chem content. I need my chemistry fix over the break.
Love the username!
I was always interested in electro chem and I’m finishing up my second semester of ochem. This video really got me hyped to see how vast electro chem can be! I don’t think I’ll end up doing this in the future, but it still looks amazing!
Oh man, I just caught a very cool flashback. I studied organic electrochemistry in my last year, when I was studying to be a chemist. It was a very cool job lasting many months, which taught me almost everything I need to be a good specialist.
A lot of what is shown here was routine for me. And even more than is shown here...
I once asked a professor who is specialised in organic electrochemistry why they don’t use the Elektrasyn. He told me that it is a nightmare to work with because the magnetic stirrer tends to break the electrodes. I forgot the other points but people like to jump on trains when it comes to high impact research
Yooo that collum holder is awesome!
Man, I absolutely love these creative synthesis videos. While I do think you a have a lot of talent as an experimental chemist, what I appreciate the mosts out of your content is your apparent theoretical knowledge and the way you share it with the public. As a new PhD student in org chem, it's amazing to finally have youtubers such as you and Chemdelic doing not only the experimental work on video but also showcasing the theoretical aspects of planning a synthesis, figuring out reaction mechanisms and ultimately pushing the boundries of science. I couldn't enjoy it more, keep up the good work❤
Ive been thinking about this topic and I'm not any type of chemist but really find it interesting
Yay electrochemistry! I just got done running a chlorate cell with mmo electrodes and an old pc power supply at 4A for 60 days ❤
Hey there sorry if I sound stupid here but in the first step of the reaction at 4:57 I do understand the mechanism but isn't it all possible using the n bromo phtalikide and the potassium or sodium salt of the acid you used? thanks if you reply in advance
Echem is awesome! Thanks for making a great video showing the emerging practicality of electrosynthesis :)
16:24 which paper did you use to establish that mechanism?
Awesome chemistry! I want to try some electrochemical organic synthesis now!
It often looks good on paper, but can be a headache in practice. A good place to start is a Kolbe synthesis because of the simple setup. Then switch to divided cells, try a 'simple' electroreduction of oxalic acid to glyoxylic acid. A PC power supply is a good source of low voltage high current, and you need a rheostat to specifically adjust current to the required current density on the electrode. When using divided cells, it is also recommended to use a reference electrode (usually calomel or silver chloride) to be able to fine-tune required voltage (all excess will convert to unwanted resistance/heat + fine tuning voltage at cathode allows for selective reductions).
thank you for your contributions to the community!! <3
Ozonolysis is the latest "new" tool in organic chemistry. The old oxidizers such as permanganate or chrome get left in the dust. Uses 95% Acetone.
It streamlines the process, leaves .HCl intact. Under 1 hour to completion.
90% yield. Pale yellow colour.
Amazing!
Ozonolysis isn't new at all, it's just the same old early 20th century methods repackaged as "green chemistry". Also ozonolysis usually requires dry ice temps, and isn't without risk, intermediate ozonides are often sensitive explosives.
where did you get the perforated funnel at 8:00 from?
Amazing stuff! Probably the first video of an electrasyn being used outside of a university lab on youtube?
It's good to see electrochemistry expand into organic chemistry. Thanks!
5:52 If you have free flowing silica I find you can use much less to adsorb your crude material than if you used celite.
Electrasyn! <3 Love to see one in wild!
Can not wait to see more with it, especially that it can be also used as analytical instrument with chronovoltamperometry
Kinda got me excited about the progesterone synthesis... any chance you're gonna do a video about prog or maybe estradiol? 🤠
Maybe in the future! Currently no plans for hormones, but I would prefer doing it chemically (without electro). My choice would probably be testosterone though ;)
@@Chemiolis Testosterone is really cool too. Without at least a little bit present, one's hippocampus would be very unhappy 😅
@@Chemiolis Going off readily-available precursors, testosterone is by far the easiest because converting between corticosteroids, progestins, androgens, and estrogens requires making/breaking double bonds without destroying everything else. DHEA is available over-the-counter in many countries and is biologically not very useful, so it's a great synthesis platform because it's an androgen you can easily convert to actual, useful testosterone in a lab with simple reduction/hydrogenation reactions. Estriol is also available OTC but not in pure form, so there IS a readily-available estrogen to do similar syntheses with if you don't mind having to extract it from like 7 bottles of menopause lotion.
@@EnUsUserScreenname you might enjoy Thy Labs. :)
@@LenKusov There exists an interesting single-step approach using biofermentation with starved, oxygen-saturated yeast, that converts DHEA into testosterone in one step. It is only suitable for small amounts though, a gram per gallon of fermented broth at best, and extraction will surely be a pain in the butt. Their approach was very interesting though, under normal conditions baker's yeast has a reducing action, but it is possible to tweak starved yeast into becoming an oxidation catalyst. They used plain baker's yeast, but it had to be pre-treated in a very specific fashion with aqueous acetaldehyde in a nutrient-poor environment and constant oxygen-enriched air bubbling for a few days. Then you add it to an aqueous suspension of DHEA and some nutrients, and keep bubbling air/oxygen in for some time, it would oxidise the DHEA to androstenedione in situ. Next you add sugar to the mixture and let it ferment in normal conditions which turns the yeast into its normal reducing mode again, and the androstenedione gets selectively reduced to testosterone.
All in all a novel and elegant approach. Still the whole madness today where people readily take hormones as if they were candy, I don't like it.
Love your work.... ❤ your opening words were very apt...
Dsng thats huge would expect nobel prize on this kind of research
Respect from a pharmacist dude cool to see technology helping to explore new methods
Thats brilliant. I always wondered if that was possble, not that i enjoyed electrochemistry. I just figured it would somehow work to perform organic chem one day.
I remember reading a write up for clandestine d amphet in a book by uncle fester back in the 90's. It called for a palladium electrode using a lambskin condom as a makeshift semi permeable membrane.
For me it says a lot about the professionalism of Chemiolis when such a well-known manufacturer as IKA sponsors their device IKA ElectraSyn 2.0 to Chemiolis.
The device itself costs €4067.00 according to IKA. IKA would not simply give such an expensive device to any YouTuber. For me it proves that Chemiolis shows an unusually high level of professionalism for a YouTuber. There are not many of those on YT. Great videos, keep it up. Greetings from a scientific colleague in the fields of biology/medicine.
Seems 4-(4-(3,4-dimethoxyphenethyl)phenyl)morpholine is a high value chemical. What is it primarily used for commercially?
Uh, you lost me at short bath distillation. This synthesis seems intense. There are a lot of steps and a new machine. You didn't even break a sweat. You understood all of it! That's truly awesome!
The process is actually called short "Path" distillation.
Cause it’s distilled directly or via a “short path” :D
Great video! I'd love to see more electro organic synthesis!
I see that someone watched Baran’s intro to his seminars multiple times 😂😂 excellent work lad
@ 7:34, if the air bubble editing you spotted was that big one in the center about 1-2 cm up, I wouldn't worry about that at least... 😅
It looks like it's in the glass itself, which would be worrying in itself, since it's a weak spot. 😕
You can see it before you loaded the column (7:17), and also on the second column (19:13).
Hate to admit, but I usually don't focus on the actual chemistry. I come here to just watch mixing of odd stuff and its outcome which feels therapeutic enough to calm my weary soul.
Sweet!!! Never seen one of these devices! Maybe I'll understand enough to use one soon 🎉
Okay, faraday's per mol is completely insane. COMPLETELY. I had to walk down a long path to even figure out how the hell any scientist thought up this unit of measure. First, you have the SI unit for electrical charge, which is coulomb. Then you have a constant called Faraday's Constant which is the amount of coulombs in 1 mol of electrons, expressed as coulombs per mol. Then you have a goofy NON STANDARD unit of measure called the faraday (little f) which is an amount of coulombs equal to Faraday's Constant times Avogadro's Number, expressed as coulombs. Then finally you have faraday's per mol which is actually... COULOMBS PER MOL AGAIN. But its worse than that! its an AMOUNT of coulombs per mol!!
Only a chemist could come up with such a foul non standard usage of SI because it contains Faraday's Constant and Avogadro's Number in such a way that it likely makes some basic algebra simpler down the line. JUST USE COULOMBS PER MOL. My brain hurts.
Oh and don't confuse this with the SI unit farad! that is 1 coulomb per volt! And you will likely deal with farads doing electrochem because they are how capacitors are characterized.
Very cool appreciate your time.
It looks promising. As a related note, there is a lot of active progress in BIOSYNTHESIS of various chemicals using genetically-altered yeasts.
Ah, but what are the PKa's and energy used .. Furthermore, can the chromatography be enhanced by 'holding' the impurity to the top with a magnetic field or light charged grid?
I stopped putting sand on the top of the columns when I was working with nitrogen heterocycles, because I would sometimes get red iron complexes eluted from the column, from the iron getting extracted/stripped by heterocycles even from the "low iron content" sand.
Just like biochemistry. E chem is black magic as well
I am writting a paper on this right now. Organophosphorus electrochemistry :) cheers
@Chemiolis - 2023-11-15
I finished this video several weeks ago already, but I had to wait before I could publish it, so this is not the only thing I have been working on since my last video! Expect more (hopefully) soon.
@mereveil01 - 2023-11-29
Benzen from acetic acid