> chemistry > divers-organiques > making-thioacetone-labcoatz

Making Thioacetone: The Worst Smelling Substance on Earth…and SMELLING IT | First-Ever Complete Demo

LabCoatz - 2022-07-18

In the late 1880’s, German chemists produced a substance with a smell so powerful, that it caused city-wide panic and nausea. Less than a hundred years later, British researchers attempted to produce that very same chemical, and ended up clearing a building. The putrid chemical behind all of this hysteria is known as thioacetone, and it is listed as the foulest-smelling substance on Earth. Only a few records detailing human interaction with it exist, and no pictures or videos of it have ever been published…until now!

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0:00 Intro sequence
0:42 What smells?
1:03 Introducing: THIOACETONE
1:54 The synthesis
4:22 The smell of success!
5:08 Trimer smell and appearance
5:48 Extracting the trimer
6:24 What next?
7:00 The big day
7:51 Thioacetone: first impressions
9:19 Smell distance test
10:59 Thioacetone: ACTUALLY SEEING IT!
12:00 Why no gagging or vomit?
13:09 Conclusion: myth confirmed?
13:30 Parting words
13:57 Patron thanks and outro
14:10 Post-credits bonus blurb

@LabCoatz_Science - 2022-12-24

A big thanks to NileRed for shouting me out! Guess now I have to do selenoacetone: thioacetone's evil selenium-based twin!

Also, since so many of you have tried correcting me on this: yes, I know natural gas is normally odorless. Saying "thioacetone smells like natural gas" is simply less confusing to most people than "thioacetone smells like mercaptan-based flammable gas odorant". As you can see at the beginning of my video when I talked about organosulfur compounds, I already correlated the smell of natural gas to ethanethiol (the mercaptan frequently added to give it a smell).

@Alanhallow - 2022-12-24

Yes

@Biaanca0089 - 2022-12-24

Hiiiii !

@ernzhang - 2022-12-24

Hi, came from NileRed, wow you beat him to it

@NileRed - 2022-12-24

I wish you luck with that lol

@lostdestroyer8400 - 2022-12-24

@@NileRed ok

@hunterpowell3319 - 2022-11-15

doing this indoors without a fume hood while your family is home is so deranged i love it

@tylera.2869 - 2022-12-24

Same! I subbed immediately after he mentioned forcing his family out of the house with the smell.

@DavidLindes - 2022-12-24

@@tylera.2869 y'all are gonna get somebody killed, encouraging this irresponsibility.

@ryhol5417 - 2023-01-01

Seriously. This dude is sumfin else

@jakodel3202 - 2023-01-15

@@dougthomson5544 welp he can do what he wants in his property.

@LittleWhole - 2023-05-11

@@Jack-ey8kt Bro had a stroke

@1brytol - 2022-07-18

Imagine spilling a vial of it in a highschool toilet. Noone would ever vape there again and the toilets will finally smell like toilets should. Horribly.

@isaacm1929 - 2022-07-18

Or the neighbors... like the Karen ones...

@davidfalconer8913 - 2022-07-25

Mercaptans work well in high school toilets ( and are easier to synthesize ! ) ...total clearout !

@1.4142 - 2022-12-24

Poor janitors would be there for hours trying to find the source

@jlbjlb - 2022-12-24

I wish I had this

@TheOneWhoHasABadName - 2022-12-24

it’s not just the toilets that would smell lol

with a sufficiently “large” amount, I’m sure the entire school will smell it. it would be so bad, it’s probably illegal to make (and “accidentally” release) this stuff in a populated area

@ed_anime7550 - 2022-12-24

One mad scientist rents an island to create the stinkiest stink bomb. Another stink bombs his own house

@ricseeds4835 - 2022-12-24

11:00 "We decided to torch the remaining trithioacetone and see what horrors would result"
I'm convinced chemists and electrical engineers are one morbid curiosity away from becoming supervillains. Looking at you, LabCoatz, NileRed, Michael Reeves and the worst one of all, StyroPyro.

@AsmodeusMictian - 2023-01-24

Styropyro is just on a different level than most. I say this while staring at the thumbnail from his "Uranium crayon" video that's currently sitting in my feed :'D

@michaelk8642 - 2023-04-17

LOL! StyroPyro. I agree on that. He is on a different level.

@patrickbrown33 - 2023-08-04

Styropyro and Nile should really get together to do a video at some point.

@Pyxis10 - 2023-09-21

And Mr Green with his I tried to make a sodium duck, and replicated electroboom twice while breaking multiple power tools.

@gorkskoal9315 - 2023-11-13

you forgot electroboom

@lasttime500 - 2022-08-16

You know someone is a chemist when that person has a high tolerance to bad smells.

Edit: How did my comment got so far all of a sudden?

@au8363 - 2022-09-26

Jesus Is King.!!!

@familyking218 - 2022-10-08

The organic chemistry professors at my university had the driest hands on earth. It seemed as if they all collectively chose to explicitly wash their hands with acetone for the past 20years 😂

@AB-80X - 2022-10-25

I'm an organic chemist and I don't actually. According to my wife, I have soft hands too lol.
My sense of humour, now that's pretty dry😀

@Jpow5734 - 2022-12-24

Yeah, NileRed just did it and he couldn’t really smell it but his friend could.

@LaffeeTaffeeGG - 2022-12-24

Nile Red basically jammed his nose into the vial, took a big whiff, and was like "eh, it's not that bad." Gives you an idea of how dead his sense of smell is.

@MrJobocan - 2022-12-25

NileRed sent me. That's some cool stuff, very nice that the papers about it are still around so you were able to find how to make it, and that it seems like the legends weren't entirely false.

@LabCoatz_Science - 2022-12-25

Not entirely false, but they do seem a bit exaggerated in my opinion (although probably not in the opinion of Nigel's friend). I'm hoping selenoacetone proves far worse! If not...telluroacetone, here I come!

@Yeetsnake - 2023-02-19

You madman!

@diarya5573 - 2022-12-24

Am always glad to see smaller science channels get a boost, I'm gonna enjoy binge watching your stuff!

@LabCoatz_Science - 2022-12-24

Hope you enjoy the content (although my new stuff is typically filmed in better quality)! Be sure to stick around for selenoacetone: thioacetone's more evil selenium-based twin!

@andyjk5974 - 2022-12-31

i just subscribed and liked the video before i even watched. came from Nilered and i know how hard it is to get there. bug up to all

@CL-we8tn - 2023-03-04

Seconded

@CL-we8tn - 2023-03-04

@@LabCoatz_Science I love garage science!

@sandman0123 - 2022-11-02

One of the coolest dads in the world, for being part of the experiment! 👍
My only suggestion is that the "distance smell test" should've been done inversely. That is, coming from a far distance and trying to find the the point when the smell can be just detected. The problem with starting nearby is that the high concentration of the substance desensitizes the nose, similarly to how when walking from strong sun into a dark room, the eyes are not as sensitive. The same thing happens to our olfactory senses.

@LabCoatz_Science - 2022-11-02

True! Additionally, we were using the mostly-depleted bottle that we had already torched, so we might've gone farther with the large sample. I should've had my Dad hangout about 500 feet downwind while I torched the large sample to see if he could smell it...

@13deadghosts - 2023-01-02

Given your reaction, I have to conclude that nilereds nose is only there for decoration and serves no actual purpose like smelling things :D
Greetings from Germany, and a happy new year :)

@lemonoxygen8846 - 2022-12-24

Nile Red just gave you a shoutout in his video on thioacetone! Great to see more crazy science content for the sake of curiosity

@Armadurapersonal - 2022-12-24

yeah but the URL in the description is wrong...

@bkarr8525 - 2022-12-24

@@Armadurapersonal boo hoo cry harder

@marcinwitkowski217 - 2022-12-24

@@Armadurapersonal nope - i got here by his url

@michaelavanduesen - 2022-12-24

@@marcinwitkowski217 same but it is possible that after someone pointed this out initially, he changed it. I'm assuming he mismatched the links to the description of the links.

@baphomet9793 - 2022-12-24

NileRed either has a super power or there is something wrong with him.

@LabCoatz_Science - 2022-12-24

I must have to same power, it wasn't that bad to me! If you hate sulfury smells like natural gas though, you'll probably take it much worse: the smell goes EVERYWHERE!

@iainballas - 2022-07-21

Imagine spilling this in a space station. I don't know why, but that's the first thing that came to mind: At some point, some bored teenagers are going to brew this up in their middle school lab, and force an evacuation of an entire habitation module.

@Extex_ - 2022-12-24

I suddenly have intense claustrophobia

@Thisandthat8908 - 2022-12-25

just open a window and the smell would be gone.

@Sparkette - 2022-12-26

How would it get from their middle school lab to the space station? Are you talking about a hypothetical time in the future when people regularly live in space stations?

@duke7803 - 2022-12-26

It happened almost that way in a friends school when someone smashed a bottle of butyric acid in a hallway.

@osamabinladen824 - 2022-12-29

@@duke7803 Really?

@parallelcircuit - 2022-12-24

It's great that you reference NileRed (well, Blue, but still) in this video and he references you in his video on thioacetone.

@bingbongthegong - 2022-12-24

do you remember when in the video?

edit: found it at 12:40 for those interested

@MozzaBallBill - 2022-12-24

❤️ from Nile, what's with you chemists having no smell!

Btw really enjoying your vids, you have a new sub

@Nefville - 2022-12-24

Here come the NileRed views. I love that your dad's wearing his dosimetry badge. You got my sub, gotta watch this RTX video.

@LabCoatz_Science - 2022-12-24

Thanks man! Hope I can keep you entertained, I'm making selenoacetone here soon! Should be much worse than thioacetone, if the legends are true!

@aye3678 - 2022-12-26

Here from Nile Red. You rock dude. First one to do it in many many years.

@harriehausenman8623 - 2022-12-26

awesome

@Andrew-pc8zn - 2022-12-24

Brought here by the shoutout in nile's thioacetone video. Good work!

@glasslinger - 2023-01-03

We had a guy named Larry where I used to work. When he would take a dump in the rest room the stink was absolutely gagging! You literally couldn't breathe in the room!

@AdvancedTinkering - 2022-07-18

Great video! I always wanted to know what this chemical smells like. Very interesting to see it tested!

@LabCoatz_Science - 2022-07-18

Thanks, glad I could help satisfy your curiosity!

@hoggif - 2022-07-18

Different people can sometimes smell things differently. You better make some of your own and then you really know what it smells like to you :D

@astralislux305 - 2022-12-25

What does it smell like?

@freddifish4179 - 2022-12-24

Looking at the rest of your content and a couple page refreshes makes me think this channel is about to go through a very large growth spurt.

@j0zart - 2022-12-24

NileRed sent me. great work!

@cheesymarshmellows - 2022-12-24

Awe im so happy for your shout out, you deserve the subs and likes, you give good details and what the chemical is and how to make it, also warning signs too! Congratulations!

@stinkyfinger777 - 2022-12-28

Now I'm going to binge watch your videos just like Nigel's. Amazing work, sir.

@bedwarsguy0207 - 2022-12-24

The only two people on youtube to make Thioacetone: LabCoatz and Nilered

@m4anow - 2022-12-30

Kudos to Dad for raising a curious child and even helping him with his stinky projects.

@chomp_5412 - 2022-12-24

Brought here by Nilered but gonna sub your vids have a much different feel and now I have yet another very enjoyable chemistry channel to keep up with.

@Chemanic1 - 2022-10-09

I love this new shift towards chemistry videos keep up the great work!

@bovanshi6564 - 2022-07-18

Great video! I can see this getting a lot of views.
If this get shared and posted around the internet it'll drive quite a bit of traffic to it I'd say!

@LabCoatz_Science - 2022-07-18

I hope so!

@tonymacaroni7069 - 2022-07-21

Got it in my recommended lol

@TruthIsTheNewHate84 - 2022-12-24

Here from NileRed. I'm glad he mentioned your channel. It's a gold mine.

@LabCoatz_Science - 2022-12-24

Glad you think so, I look forward to producing more unique content for people like you!

@bazd313 - 2022-11-05

How you don't have millions of subscribers is beyond me. Keep doing your thing and il be watching great interesting stuff. 👍

@whoever6458 - 2023-11-02

I came over from Nile Red's channel. Looking forward to watching more of your videos. I partially dreaded having to take chemistry for my biology degree but, when I actually took the classes, especially the labs, I loved it! Keep up the good work!

@SH-ny8oz - 2023-01-06

You have a new fan and sub. I really enjoy the comment section. You truly do communicate with people who follow you. You give shouts for appreciating other YouTubers, and the comments are mature, helpful, no trolls. Everyone here has my respect

@SaltNBattery - 2022-12-24

Came here from Nile Red's Thioacetone video. He mentioned you'd done it first and tried to link your video. Unfortunately, his link to your video, sends you to a video of baby pandas.

@justinbanks2380 - 2022-07-19

Very cool video!

And nice to see the tests of distance you could smell outside.

Nice cameo of your dad. (Does he work with or around radiation? Looks like a dosimeter on his collar.)

@LabCoatz_Science - 2022-07-19

Thanks, and yes, my father is a mobile x-ray tech (he was actually on call that day, hence the scrubs). Come to think of it, I really should be taking advantage of the fact that we have a $20,000 worth of x-ray equipment lying around...maybe I'll do a future video featuring it!

@justinbanks2380 - 2022-07-19

@@LabCoatz_Science if you can, that would be very interesting to learn about

@poisonouspotatou - 2022-12-26

225 feet with just that little amount!!!
in the original experiment carried out years ago they used 100g of that final substance.....that was a catastrophe!!!!

@yashuchaudhary9003 - 2022-12-24

came here from nile red's video , he gave you credit of making thioacetone before he knew

@JPaterson8942 - 2022-07-20

I heard about this recently and was so disappointed that there weren't any videos. Very interesting.

@geeseispluralforgoose - 2023-01-01

That’s super interesting! I came from nilered’s video but mostly because i wanted to hear a second opinion on this. And its cool you both gave each other a shoutout

@everythingexplained3226 - 2022-07-18

Good job.
If you are looking for ideas,
Try to replace the Sulfur atom with selenium/thallium.
It is said that thallium/selenium analogues of organosulfur compounds smell worse.

@LabCoatz_Science - 2022-07-18

I would, but unlike the sulfur-based ones, selenium and tellurium based ones are much more toxic and less stable. Maybe someday though, if I can do it easily and safely...

@oitthegroit1297 - 2022-07-24

@@LabCoatz_Science You should try making benzeneselenol, aka selenophenol, the selenium analog of phenol. In Derek Lowe's "Things I Won't Work With" series, one of the chemicals he describes is selenophenol. I'm paraphrasing here, but he says that, according to the researchers working with it, it smelled like putting a bunch of skunks in rubber tubing, then setting the whole thing ablaze. It would be interesting to see you synthesize it.

@kauspet - 2022-10-07

Hope there are more likes to this video. Real hard work involved here not to mention risks 👏

@tonythepwny - 2022-12-25

Man, this video was way better than the dude's who has like 4+ million subs. Didn't even have to rent an island to make good content.

@lucasjones3338 - 2022-12-24

1880's Germany residents living next to a lab were probably already extremely suspicious and superstitious of the lab. So maybe they overexaggerated.

@theexchipmunk - 2022-12-27

But accounts from later incidents back it up. One thing to consider is the one common thing in these storys. People initially exposed by the more concetrated release didn´t react as bad, but the people further away got hit badly. And so far we only have seen people close by to the initial release react.

@sdaafasfad - 2022-12-24

NileRed sent me. Subscribed. Really enjoyed watching this straight after Niles!

@peterdekker8545 - 2022-07-23

11:25 "It added this kind of oniony garlic stuff to it".......
Makes me wonder if thioacetone in these conditions is able to oxidize to dimethyl sulfate, which is basically thioacetone with 4 added oxygen atoms.
And dimethyl sulfate does have an onion-like odor....although smelling that odor already poses a threat as dimethyl sulfate is extremely toxic......and carcinogenic....and mutagenic....etc, etc.
So, be careful with what you smell...... 😉

@michaelbell8834 - 2022-10-25

I don't think a pathway readily exists to DMSO4 from thioacetone.

@kelownatechkid - 2022-12-27

This is awesome. Really glad nilered shared it, you totally earned the new subscribers (myself among them)

@LabCoatz_Science - 2022-12-27

Thanks, glad to have you aboard! Hopefully I can continue to make your stay worthwhile!

@war_kittens - 2022-12-27

Excellent job my friend. I like how you and Nigel ended up coming at the reaction from opposite sides.

@davedcobern319 - 2023-01-08

Dude!!!!! Fantastic job! Way to keep it real !!!! Thank you for taking the time to post this!!!

@gnorts_mr_alien - 2022-12-26

If books describing those times, written in those times are any indication, people fainted even upon hearing slightly bad news.

@LabCoatz_Science - 2022-12-26

Yeah, the odor really was a bit exaggerated (for me at least...not so much Nigel's friend). Although the stink did spread EVERYWHERE!

@dustieboots546 - 2023-01-08

I love your content! I've been binge watching your videos today. Also, you're very active with your comments.I can see you getting millions of subs in the future just like nilered. Keep it up!