Thy Labs - 2021-08-20
In this video we are preparing acetic anhydride from acetyl chloride and anhydrous sodium sulfate. This video is for demonstration purposes only. In many places acetic anhydride is illegal. Make sure to check the laws in your country yourself before even thinking about this synthesis.
Thank you for your tutorial, acetic anhydride is a strictly controlled substance in our country, it cannot be sold to any individual. I can continue my research with your help, really appreciate it my man. 😄
Very nicely executed classic synthesis! Subscribed to Your channel. I think Youtube really makes young people interested in chemistry again. Except for the drug idiots it seems like practical lab skills have been on the decline, which I do not think is good for science. It is sort of sad that many basic lab chemicals are restricted nowadays. Personally I do not believe it has any effect on the targeted illegal audience. It is just something easy to show for politicians instead of dealing with druggies and terrorists properly. I have had a lab since the age of 12 and many of my successful colleagues have the same background.
Sad but very true...
How does this guy have:
The time to do this,
The legal ability to do this,
The motivation to do this.
I got a degree in chemistry which I may as well burn. I haven’t had the opportunity to run a reaction since I graduated.
I guess burning it would be running a reaction 😋
You can dispose of chemical waste for free in Germany
@Glenn McEnroe as long as you bring John. No matter of enforcement anyways. I didn’t specify which phenethylamine? Where is John?
@Walter Sobchak My grandson John is only 4, it's past his bedtime.
@Glenn McEnroe never mind you never heard of John? John McEnroe?
In certain cases with controlled chemicals (like sodium cyanide, in other words extremely hazardous chemicals) at least in South Australia, Australia where I live chemicals like cyanides and concentrated hydrofluoric acid are tightly restricted but are legitimate to buy, store, handle, use or sell with an appropriate relevant permit or licence to do so. For example University campuses in South Australia are legally allowed to possess and use extremely hazardous chemicals like concentrated hydrofluoric acid and sodium cyanide, or chemicals like sodium metal which are classified as precursor chemicals that can be misused to manufacture illicit drugs with appropriate relevant permits or licenses. One example is concentrated hydrofluoric acid which is extremely hazardous due to being dangerously corrosive and toxic, hydrofluoric acid is not available to general members of the public but if an individual or organisation like a university has a valid poisons licence from the state government it is then permitted to purchase and store, handle or use the concentrated hydrofluoric acid as long as there's a legitimate reason to be in possession of it
You can make it with a.mixture of sodium acetate and a little bit of sodium pyrophosphate to start the reaction. Heat to decomposition, you get sodium phosphate, acetic anhydride, and sodium carbonate as the reaction proceeds.
This is the only good preparation of acetic anhydride I`ve found on YouTube, but the acetyl chloride is almost impossible to get hold of in both my country and probably many others. I`ve tried to chlorinate white phosphorus to form phosphorus trichloride just to be able to make acetyl and benzoyl chloride, but it`s way too much work for a few drops of anhydride. I might have to take a trip to Germany to go shopping for chemicals it seems.
Another viable but highly dangerous route is the ketene process. Unless you know what you are doing and don’t have appropriate safety precautions and PPE you should stay far away from it.
@Thy Labs Yeah, I think Dug`s Lab has one on the ketene process. That`s some nasty fumes you`re generating while heating the acetone though. Setup needs to be close to perfect too. It`s not exactly a project for the novice chemist. Chlorine gases are a little bit easier to handle then running a ketene lamp.
Very good vídeo👍 more for the organic chemistry
Nice video, I'm jealous your able to access acetyl chloride in your country!
@Noodle soup dude mexican ebay has a cod with the right seller he wont speak english u feel me? A jug costs $390 it's a big black jug
@anonymous anonymous i recommend not buying stuff from companies like that, you can get 1L of acetic anhydride for 15$ plus shipping if you just ask a couple people in forums or discords....
@Contomo asking on forums gets you a fed and they charge you with conspiracy to manufacture fentanyl/heroin thats why i only trust the cartels
@anonymous anonymous well, maybe youre just not looking for the right people then :P
@Thy Labs I found out about SOCl2-containing batteries which could wasily be used to produce any acid chloride or even alkyl chloride from alcohols. I haven‘t looked out for any vendors tho.
Can this reaction be done with calcium acetate as well?
Yes! It must be anhydrous thoug
At least hydrogen chloride (HCl) vapours while still toxic and corrosive are less dangerous and easier to handle than hydrogen fluoride (HF) vapours. I'm not saying that hydrogen chloride vapours aren't dangerous rather I'm saying that their easier to work with than hydrogen fluoride HF vapours although hydrogen chloride vapours are still dangerous and should be handled very carefully with appropriate PPE
Fantástico .
Btw, hot oil bath is much better than heating mantle for this experiment. More acetic anhydride will be collected and there will be no tar formation
if you have a hot oil bath go for it
Wait, acetyl chloride is a compound that can replace acetic anhydride, and you prepared acetic anhydride from acetyl chloride??
Acetyl chloride isn’t suited for every reaction. Besides that it is a burden to work with
Why is the amount of acetic anhydride(39ml) is more than that acetyl chloride?
You get another acetate from the sodium acetate and thus the volume will increase. From 1 mol of acetyl chloride (AcCl) you can get 1 mol of acetic acid when it reacts with water. When acetic anhydride (Ac2O) reacts with water you get two mol of acetic acid for each mol of anhydride
what if you mix 99% acetic acid with P2O5 ? would that create this compound?
I’ve read numerous patents on that route. It should definitely work.
won't that cause a secondary dehidration to ketene? (and nobody wants that!)
@Costi Ekzeme Production requires extremely high temperatures
@Thy Labs Patents aren't always trustworthy though, or they leave out important details. There are also patents that claim Ac2O production from hexametaphosphate and AcOH but nobody seems to have get it to work at this point.
Very nice video - but I was surprised there was no fume hood used - perhaps the vapors would destroy the hood -- LOL
Neutralized by NaOH solution trough the vacuum adapter maybe?
...PERFECT!
Did you know that if you mix salt vinegar and hydraulic acid the acetolation of salt is exsplosive
What is salt vinegar, what is hydraulic acid, what is "acetolation of salt"?
its possible to make it with acetone?
Yes but the ketone route is extremely dangerous
0:35 , I have that same stir-plate. Nice!
@Thy Labs awesome! I would love to discuss it over reddit. My name on there is the same as on here and I am fairly active in the r/elementcollection community. I am also on vacation, so I am free to talk anytime for the next week. 😃
I’ve seen your nice HUGE element samples there. I’ll hit you up on Reddit now :D
@BackYard Science 2000 you are always so supportive of the YouTube chemistry community, thank you for making it a better place!
@Thy Labs sounds good man! I'm about to start driving, so when I get done and get to where I am going I will answer back. It may be a bit though. 🙂
@Chemistry of Questionable Quality thank you for your kind words! I'm just trying to help out, is all. People who choose to educate others on chemistry deserve some support, and I try my best to give them that. The better that they do the better the whole community does. And that's what I like to see. That, and I just like helping others. It's such a good feeling to see people do great and awesome things with the stuff that I send them. 🙂
Ohh, man. I do hate HCl too.
Where do you get those Teflon cap bottles?
at one of my two local lab shops. you can get them on the web but there they are often overpriced
@Thy Labs Where would you recommend? Especially for one that could include a septum... How much are they at your local shop? (Just for a point of reference)
Whats next, octyl acetate or butyl acetate?
Maybe cetyl- or phenyl acetate
@Thy Labs p-nitrophenyl acetate maybe? Has IRL applications too in things like enzyme kinetics and chemical tagging.
How your acetic anhydride is Crystal clear?
If it is pure it is clear
Can't you prepare acetyc anhydride from acetic acid?
It is possible with strong dehydration agents like P2O5. These however come at a price.
You can prepare acetic anhydride from acetic acid by reaction with ketene. Its how its done on industrial scale.
Didn’t know toxicity was an opinion probably unpopular
ok now you just need to make the morphine too
CAN YOU SUGGEST THE WAY OF MAKING CELLULOSE ACETATE WITHOUT USING ACETIC ANHYDRIDE
USE ACETYL CHLORIDE INSTEAD
TO PREPARE 1 LITER OF ANHYDRIDE ACETIC,HOW MUCH OF SODIUM ANHYDRIDOUS ACETATE AND HOW MUCH OF ACETYL CHLORIDE TO USE ?
If you cant figure that out yourself you shouldn’t be making it in the first place. Besides that there are measurements in the video.
@Thy Labs 😂😂
Why it isn't allowed in view country's?
In Russia it’s illegal because of drug manufacture
heroin
Walter White looks on with approval.
Si es anihdrido acético que pureza %???
Should be between 95-100%
@Thy LabsHola
It's very very hard to distill not easy
It’s really easy in my opinion. At least with the equipment I have it was easy
@Thy Labs is dropping of acetyl chloride necessary or I can pour it directly with bit slow
You can pour it in directly but make sure to cool the flask sufficiently so it doesn’t start to boil
@Thy Labs thank you
someone poured my litre of aa down the drain very unhappy i was
cool
Solo un pregunta es acetato de sodio o cloruro de acetilo ????
English please
What is sodium acetate or acetyl cloruro de acetilo
C2H3NaO2
Or
CH3COONa
Which one should I buy ? Plz reply
Aren´t these the same? Just take the second one
@Thy Labs but in this video sir you use c2h3na02
.
I search sodium acetate anhydrous
Google show sodium acetate
But than i search sodium acetate it show ch3coona
@14 gamer perhaps don’t attempt this synthesis without even basic chemistry knowledge 💀
why not using acetic acide withe consentrate sulferic acide to obtein anhydride acetic because acetic chloride is Expensive, rare and dangerous
Firstly the method you described would sadly not work for making Ac2O. Secondly getting acetyl chloride was cheap and easy for me. In the future we are going to explore easier methods to make Ac2O
You can make acetyl chloride from benzoyl chloride and acetate. Benzoyl chloride isn't that hard to get.
Hindi me bnaye
Datura seeds, acetic anhydride... something stinks, and it's not the hcl vapors
Definetely not mate. I just like collecting toxic stuff.
Ya FIR isase sahi se banana sikhayen
Ist das AcCl von S3 ?
@Thy Labs und das bekommt man einfach so? Ist ja nicht gerade ungefährlich so als Säurechlorid
Das denke ich mir auch aber es gibt darauf derzeit keinerlei Beschränkungen da es nur mit brennbar, ätzend und Achtung deklariert ist. Ich finde da gehört aufgrund der massiven HCl Entwicklung noch ein Totenkopf drauf. Gefährliches Zeug wenn jemand nicht weiß womit er gerade hantiert.
@Thy Labs Ich hätte mir jetzt weniger Sorgen wegen des Stoffes an sich gemacht, da hab ich an der Uni schon mit weitaus schlimmeren gearbeitet. Ich Frage mich eher ob man da nicht auf irgendwelche listen kommt. Ich mein, es wäre ja durchaus eine alternative für Essigsäureanhydrid bzw ein Vorläufer davon, und Essigsäureanhydrid ist ja nicht ohne Grund schwer zugänglich.
Dafür kommt man bestimmt auf listen aber da ich sowieso nichts verbotenes herstelle und aufgrund meiner YouTube Videos den Verwendungszweck und Verbleib nachweisen kann mache ich mir da eher weniger sorgen.
@Thy Labs ja, wäre halt trotzdem nervig da rechtliche verfahren aufgedrückt zu bekommen obwohl dann letztenendes natürlich nichts bei rauskommen würde 🤷♂️
Hell yeah! Gonna make some heroin now!
Don’t
Yah online mere ko bhej sakte hain acidic acid mere ko online bhej sakte hain kya kripya thoda bahut bhi bhej dijiye mere ko madhumakkhiyon ke liye chahie
Can you write that comment in english? My translator doesn´t work correctly
hey, now you can make heroin!
no
@Thy Labs you have one of required ingredients....
Which has multiple other uses besides making drugs
Costi - 2022-01-04
You accidentally wrote "sodium sulfate" instead of "sodium acetate" in the description